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GPCR

Name5-hydroxytryptamine receptor 4
SpeciesMus musculus (Mouse)
GeneHtr4
Synonym5-HT-4
5-HT4
5-HT4 receptor
5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled
serotonin receptor 4
DiseaseN/A for non-human GPCRs
Length388
Amino acid sequenceMDKLDANVSSNEGFRSVEKVVLLTFLAVVILMAILGNLLVMVAVCRDRQLRKIKTNYFIVSLAFADLLVSVLVMPFGAIELVQDIWAYGEMFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNKMTPLRIALMLGGCWVLPMFISFLPIMQGWNNIGIVDVIEKRKFSHNSNSTWCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAQQIQMLQRAGATSESRPQPADQHSTHRMRTETKAAKTLCVIMGCFCFCWAPFFVTNIVDPFIDYTVPEQVWTAFLWLGYINSGLNPFLYAFLNKSFRRAFLIILCCDDERYKRPPILGQTVPCSTTTINGSTHVLRDTVECGGQWESRCHLTATSPLVAAQPSDT
UniProtP97288
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL2183
IUPHAR9
DrugBankN/A

Ligand

Namemetoclopramide
Molecular formulaC14H22ClN3O2
IUPAC name4-amino-5-chloro-N-[2-(diethylamino)ethyl]-2-methoxybenzamide
Molecular weight299.799
Hydrogen bond acceptor4
Hydrogen bond donor2
XlogP2.6
SynonymsBenzamide,4-amino-5-chloro-N-[2-(diethylamino)ethyl]-2-methoxy-
Maxeran
BRN 1884366
Metaclopramide
Cerucal
[ Show all ]
Inchi KeyTTWJBBZEZQICBI-UHFFFAOYSA-N
Inchi IDInChI=1S/C14H22ClN3O2/c1-4-18(5-2)7-6-17-14(19)10-8-11(15)12(16)9-13(10)20-3/h8-9H,4-7,16H2,1-3H3,(H,17,19)
PubChem CID4168
ChEMBLCHEMBL86
IUPHAR241
BindingDB48320
DrugBankDB01233

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Ki891.25 nMPMID8946946BindingDB
Ki1000.0 nMPMID8946946IUPHAR
Ki3981.07 nMPMID8867105, PMID8946946BindingDB

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