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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Prostaglandin D2 receptor 2
Species	Mus musculus (Mouse)
Gene	Ptgdr2
Synonym	PGD2 receptor Gpr44 G-protein coupled receptor 44 G protein-coupled receptor 44 DP2 receptor CRTH2 Chemoattractant receptor-homologous molecule expressed on Th2 cells CD294 prostaglandin D2 receptor 2 [ Show all ]
Disease	N/A for non-human GPCRs
Length	382
Amino acid sequence	MANVTLKPLCPLLEEMVQLPNHSNSSLRYIDHVSVLLHGLASLLGLVENGLILFVVGCRMRQTVVTTWVLHLALSDLLAAASLPFFTYFLAVGHSWELGTTFCKLHSSVFFLNMFASGFLLSAISLDRCLQVVRPVWAQNHRTVAVAHRVCLMLWALAVLNTIPYFVFRDTIPRLDGRIMCYYNLLLWNPGPDRDTTCDYRQKALAVSKFLLAFMVPLAIIASSHVAVSLRLHHRGRQRTGRFVRLVAAIVVAFVLCWGPYHIFSLLEARAHSVTTLRQLASRGLPFVTSLAFFNSVVNPLLYVFTCPDMLYKLRRSLRAVLESVLVEDSDQSGGLRNRRRRASSTATPASTLLLADRIPQLRPTRLIGWMRRGSAEVPQRV
UniProt	Q9Z2J6
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL2291
IUPHAR	339
DrugBank	N/A

Ligand

Name	delta(12)-PGJ2
Molecular formula	C20H30O4
IUPAC name	(Z)-7-[(1S,5E)-5-[(3S)-3-hydroxyoctylidene]-4-oxocyclopent-2-en-1-yl]hept-5-enoic acid
Molecular weight	334.456
Hydrogen bond acceptor	4
Hydrogen bond donor	2
XlogP	3.9
Synonyms	ZINC4096983 102839-03-2 9-Deoxy-delta(9,12)-13,14-dihydro PGD2 CHEBI:28130 delta(12)-Prostaglandin J2 HMS1361A06 NCGC00161301-01 1703AH AC1NQXQ4 d12-PGJ2 delta-12-Prostaglandin D2 HMS3402A06 Prosta-5,9,12,13-tetraen-1-oic acid, 15-hydroxy-11-oxo-, (5Z,15S)- SR-01000946874 (Z)-7-[(1S,5E)-5-[(3S)-3-hydroxyoctylidene]-4-oxo-1-cyclopent-2-enyl]hept-5-enoic acid 9-Deoxy-9,10-didehydro-12,13-didehydro-13,14-dihydroprostaglandin D2 BSPBio_001284 delta(12)-Pgj(2) delta12-PROSTAGLANDIN J2 LS-178022 11-oxo-15S-hydroxy-5Z,9Z,13E-prostatrienoic acid 9-Deoxy-delta-9,12-pgd2 CHEMBL519797 Delta-12 PGJ-2 HMS1791A06 NCGC00161301-02 BML2-B02 D12-prostaglandin J2 delta-12-Prostaglandin J2 IDI1_033754 Prosta-5,9,12-trien-1-oic acid, 15-hydroxy-11-oxo-, (5Z,12E,15S)- SR-01000946874-1 (Z)-7-[(1S,5E)-5-[(3S)-3-hydroxyoctylidene]-4-oxocyclopent-2-en-1-yl]hept-5-enoic acid 9-Deoxy-delta(9), delta(12)-13,14-dihydroprostaglandin D2 C05958 GTPL1876 MolPort-027-640-982 13,14-dihydro-Delta(12)-prostaglandin J2 9-Deoxy-delta-9,12-prostaglandin D2 D0MS3D delta-12-PGJ2 HMS1989A06 NCGC00161301-03 (5Z,12E,15S)-15-hydroxy-11-oxoprosta-5,9,12-trien-1-oic acid 87893-54-7 BRD-K83820346-001-02-5 Dddd-PGD2 Delta12-PGJ2 LMFA03010020 SCHEMBL3368873 [ Show all ]
Inchi Key	TUXFWOHFPFBNEJ-GJGHEGAFSA-N
Inchi ID	InChI=1S/C20H30O4/c1-2-3-6-10-17(21)13-14-18-16(12-15-19(18)22)9-7-4-5-8-11-20(23)24/h4,7,12,14-17,21H,2-3,5-6,8-11,13H2,1H3,(H,23,24)/b7-4-,18-14+/t16-,17-/m0/s1
PubChem CID	5280885
ChEMBL	N/A
IUPHAR	1876
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	398.107 nM	PMID12721327	IUPHAR

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