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GLASS

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GPCR

Name	D(4) dopamine receptor
Species	Homo sapiens (Human)
Gene	DRD4
Synonym	D4 receptor D4R Dopamine D4 receptor dopamine receptor 4 d(2C) dopamine receptor
Disease	Erectile dysfunction Psychotic disorders Schizophrenia
Length	467
Amino acid sequence	MGNRSTADADGLLAGRGPAAGASAGASAGLAGQGAAALVGGVLLIGAVLAGNSLVCVSVATERALQTPTNSFIVSLAAADLLLALLVLPLFVYSEVQGGAWLLSPRLCDALMAMDVMLCTASIFNLCAISVDRFVAVAVPLRYNRQGGSRRQLLLIGATWLLSAAVAAPVLCGLNDVRGRDPAVCRLEDRDYVVYSSVCSFFLPCPLMLLLYWATFRGLQRWEVARRAKLHGRAPRRPSGPGPPSPTPPAPRLPQDPCGPDCAPPAPGLPRGPCGPDCAPAAPGLPPDPCGPDCAPPAPGLPQDPCGPDCAPPAPGLPRGPCGPDCAPPAPGLPQDPCGPDCAPPAPGLPPDPCGSNCAPPDAVRAAALPPQTPPQTRRRRRAKITGRERKAMRVLPVVVGAFLLCWTPFFVVHITQALCPACSVPPRLVSAVTWLGYVNSALNPVIYTVFNAEFRNVFRKALRACC
UniProt	P21917
Protein Data Bank	5wiv, 5wiu
GPCR-HGmod model	P21917
3D structure model	This structure is from PDB ID 5wiv.
BioLiP	BL0394824, BL0394826, BL0394825
Therapeutic Target Database	T24983
ChEMBL	CHEMBL219
IUPHAR	217
DrugBank	BE0009376, BE0000389

Ligand

Name	fenoldopam
Molecular formula	C16H16ClNO3
IUPAC name	9-chloro-5-(4-hydroxyphenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine-7,8-diol
Molecular weight	305.758
Hydrogen bond acceptor	4
Hydrogen bond donor	4
XlogP	2.4
Synonyms	9-chloro-5-(4-hydroxyphenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine-7,8-diol;mesylic acid Tox21_110152 AC1L1FPQ BPBio1_001265 CC-28388 CS-2979 DTXSID0043896 FT-0641107 LS-27993 NCGC00015444-07 6-chloro-1-(4-hydroxyphenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine-7,8-diol SK&F-82526J SKF 82526 AB0013872 VA10891 AN-38412 C-20379 HMS3715H14 MolPort-006-167-637 PDSP1_001661 67227-57-0 (mesylate) SKF-82526J AB00698256_16 BDBM60917 Carlacor (TN) Corlopam DSSTox_GSID_43896 Fenoldopamum L000254 NCGC00015444-05 1H-3-Benzazepine-7,8-diol, 6-chloro-2,3,4,5-tetrahydro-1-(4-hydroxyphenyl)- SCHEMBL34250 9-chloranyl-5-(4-hydroxyphenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine-7,8-diol;methanesulfonic acid 9-chloro-5-(4-hydroxyphenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine-7,8-diol;methanesulfonic acid Tox21_110152_1 AC1Q3LHG BRD-A50684349-001-01-5 CCG-204646 D07946 EN300-119508 GTPL939 MCULE-7876003953 NCGC00025246-02 SK-82526 SKF 82526-J AB00698256-13 API0007253 C07693 CHEMBL588 DB00800 Fenoldopam (INN) HY-B0735 NCGC00015444-03 (R)-6-Chloro-2,3,4,5-tetrahydro-1-(4-hydroxyphenyl)-1H-3-benzazepine-7,8-diol PDSP2_001645 67287-54-1 (hydrobromide) 9-chloro-5-(4-hydroxyphenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine-7,8-diol SMR000469190 AB2000493 Biomol-NT_000042 CAS-67227-56-9 Corlopam (TN) DSSTox_RID_80083 Fenoldopamum [Latin] Lopac0_000556 NCGC00015444-06 27F569 SK&F-82526 TVURRHSHRRELCG-UHFFFAOYSA-N AKOS015906543 BRD-A50684349-003-01-1 CHEBI:5002 D0R6BI Fenodopam mesylate HMS2090G16 MLS001401388 NCGC00025246-03 67227-56-9 SK-82526-J SKF-82526 AB00698256-15 BC220528 Carlacor cid_49659 DSSTox_CID_23896 Fenoldopam [INN:BAN] I745 NCGC00015444-04 SCHEMBL13287212 87900-90-1 [ Show all ]
Inchi Key	TVURRHSHRRELCG-UHFFFAOYSA-N
Inchi ID	InChI=1S/C16H16ClNO3/c17-15-11-5-6-18-8-13(9-1-3-10(19)4-2-9)12(11)7-14(20)16(15)21/h1-4,7,13,18-21H,5-6,8H2
PubChem CID	3341
ChEMBL	CHEMBL588
IUPHAR	939
BindingDB	60917
DrugBank	DB00800
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	316.228 nM	PMID1840645	IUPHAR

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