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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Prostaglandin D2 receptor
Species	Homo sapiens (Human)
Gene	PTGDR
Synonym	PGD2 receptor DP1 DP1 receptor PTGDR1 prostanoid DP receptor-like Prostanoid DP receptor prostaglandin D2 receptor (DP) PGD receptor [ Show all ]
Disease	Pain Dyslipidaemias Rhinitis Thromboembolism Thrombosis Atopic dermatitis Asthma Allergy Allergic rhinitis [ Show all ]
Length	359
Amino acid sequence	MKSPFYRCQNTTSVEKGNSAVMGGVLFSTGLLGNLLALGLLARSGLGWCSRRPLRPLPSVFYMLVCGLTVTDLLGKCLLSPVVLAAYAQNRSLRVLAPALDNSLCQAFAFFMSFFGLSSTLQLLAMALECWLSLGHPFFYRRHITLRLGALVAPVVSAFSLAFCALPFMGFGKFVQYCPGTWCFIQMVHEEGSLSVLGYSVLYSSLMALLVLATVLCNLGAMRNLYAMHRRLQRHPRSCTRDCAEPRADGREASPQPLEELDHLLLLALMTVLFTMCSLPVIYRAYYGAFKDVKEKNRTSEEAEDLRALRFLSVISIVDPWIFIIFRSPVFRIFFHKIFIRPLRYRSRCSNSTNMESSL
UniProt	Q13258
Protein Data Bank	N/A
GPCR-HGmod model	Q13258
3D structure model	This predicted structure model is from GPCR-EXP Q13258.
BioLiP	N/A
Therapeutic Target Database	T68782
ChEMBL	CHEMBL4427
IUPHAR	338
DrugBank	BE0000296

Ligand

Name	prostaglandin J2
Molecular formula	C20H30O4
IUPAC name	(Z)-7-[(1S,5R)-5-[(E,3S)-3-hydroxyoct-1-enyl]-4-oxocyclopent-2-en-1-yl]hept-5-enoic acid
Molecular weight	334.456
Hydrogen bond acceptor	4
Hydrogen bond donor	2
XlogP	3.6
Synonyms	(Z)-7-[(1S,5R)-5-[(E,3S)-3-hydroxyoct-1-enyl]-4-oxo-cyclopent-2-en-1-yl]hept-5-enoic acid 8-epi-15-J2t-IsoP C05957 HMS1989K20 NCGC00161294-02 SR-05000002330-2 11-oxo-15S-hydroxy-5Z,8Z,13E-prostatrienoic acid AC1NQXQ1 D0Y6OX IDI1_033968 Prosta-5,9,13-trien-1-oic acid, 15-hydroxy-11-oxo-, (5Z,13E,15S)- ZINC12496015 (5Z,13E,15S)-15-hydroxy-11-oxoprosta-5,9,13-trien-1-oic acid BRD-K56811497-001-03-2 HMS1361K20 MolPort-003-959-398 SMP2_000100 (Z)-7-[(1S,5R)-5-[(E,3S)-3-hydroxyoct-1-enyl]-4-oxocyclopent-2-en-1-yl]hept-5-enoic acid 9-Deoxy-delta-9-pgd2 CHEBI:27485 HMS3402K20 NCGC00161294-03 SR-05000002330-3 11-oxo-15S-hydroxy-5Z,9,13E-prostatrienoic acid AKOS024418774 DTXSID4041105 LMFA03010019 (Z)-7-[(1S,5R)-5-[(E,3S)-3-hydroxyoct-1-enyl]-4-oxo-1-cyclopent-2-enyl]hept-5-enoic acid 60203-57-8 BSPBio_001498 HMS1791K20 NCGC00161294-01 SR-05000002330 11-oxo-15S-hydroxy-5Z,8Z,13E-prostatrienoate 9-Deoxy-delta-9-prostaglandin D2 CHEMBL1397260 HMS3648L18 PGJ2 UQOQENZZLBSFKO-POPPZSFYSA-N 11-oxo-15S-hydroxy-5Z,9,13E-prostatrienoic acid-cyclo[8S,12R] BML1-G07 GTPL1885 LS-176073 SCHEMBL5700581 [ Show all ]
Inchi Key	UQOQENZZLBSFKO-POPPZSFYSA-N
Inchi ID	InChI=1S/C20H30O4/c1-2-3-6-10-17(21)13-14-18-16(12-15-19(18)22)9-7-4-5-8-11-20(23)24/h4,7,12-18,21H,2-3,5-6,8-11H2,1H3,(H,23,24)/b7-4-,14-13+/t16-,17-,18+/m0/s1
PubChem CID	5280884
ChEMBL	N/A
IUPHAR	1885
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	1.0 nM	PMID9579725	IUPHAR

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