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GPCR

NameProstaglandin F2-alpha receptor
SpeciesHomo sapiens (Human)
GenePTGFR
SynonymProstanoid FP receptor
prostaglandin F2-alpha receptor
prostaglandin F receptor (FP)
prostaglandin F receptor
PGF2-alpha receptor
[ Show all ]
DiseaseGlaucoma
Ocular disease
Renal cancer
Dysmenorrhea
Alzheimer disease
[ Show all ]
Length359
Amino acid sequenceMSMNNSKQLVSPAAALLSNTTCQTENRLSVFFSVIFMTVGILSNSLAIAILMKAYQRFRQKSKASFLLLASGLVITDFFGHLINGAIAVFVYASDKEWIRFDQSNVLCSIFGICMVFSGLCPLLLGSVMAIERCIGVTKPIFHSTKITSKHVKMMLSGVCLFAVFIALLPILGHRDYKIQASRTWCFYNTEDIKDWEDRFYLLLFSFLGLLALGVSLLCNAITGITLLRVKFKSQQHRQGRSHHLEMVIQLLAIMCVSCICWSPFLVTMANIGINGNHSLETCETTLFALRMATWNQILDPWVYILLRKAVLKNLYKLASQCCGVHVISLHIWELSSIKNSLKVAAISESPVAEKSAST
UniProtP43088
Protein Data BankN/A
GPCR-HGmod modelP43088
3D structure modelThis predicted structure model is from GPCR-EXP P43088.
BioLiPN/A
Therapeutic Target DatabaseT75797
ChEMBLCHEMBL1987
IUPHAR344
DrugBankBE0000610

Ligand

NameSulprostone
Molecular formulaC23H31NO7S
IUPAC name(Z)-7-[(1R,2R,3R)-3-hydroxy-2-[(E,3R)-3-hydroxy-4-phenoxybut-1-enyl]-5-oxocyclopentyl]-N-methylsulfonylhept-5-enamide
Molecular weight465.561
Hydrogen bond acceptor7
Hydrogen bond donor3
XlogP1.5
SynonymsMFCD00216056
SR-01000946436
Sulprostone, >=95% (HPLC), oil
(5Z)-7-[(1R,2R,3R)-3-Hydroxy-2-[(1E,3R)-3-hydroxy-4-buten-1-yl]-5-oxocyclopentyl]-N-(methylsulfonyl)-5-heptenamide
16-Phenoxy-omega-17,18,19,20-tetranor prostaglandin E2 methylsulfonylamide
[ Show all ]
Inchi KeyUQZVCDCIMBLVNR-TWYODKAFSA-N
Inchi IDInChI=1S/C23H31NO7S/c1-32(29,30)24-23(28)12-8-3-2-7-11-19-20(22(27)15-21(19)26)14-13-17(25)16-31-18-9-5-4-6-10-18/h2,4-7,9-10,13-14,17,19-20,22,25,27H,3,8,11-12,15-16H2,1H3,(H,24,28)/b7-2-,14-13+/t17-,19-,20-,22-/m1/s1
PubChem CID5312153
ChEMBLN/A
IUPHAR1919
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Ki199.526 nMPMID10634944IUPHAR

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