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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Hydroxycarboxylic acid receptor 1
Species	Mus musculus (Mouse)
Gene	Hcar1
Synonym	lactate receptor 1 LACR1 HCA1 receptor Gpr81 G-protein coupled receptor 81 G protein-coupled receptor 81 G protein-coupled receptor 104 FKSG80 T-cell activation G protein-coupled receptor [ Show all ]
Disease	N/A for non-human GPCRs
Length	343
Amino acid sequence	MDNGSCCLIEGEPISQVMPPLLILVFVLGALGNGIALCGFCFHMKTWKSSTIYLFNLAVADFLLMICLPLRTDYYLRRRHWIFGDIACRLVLFKLAMNRAGSIVFLTVVAVDRYFKVVHPHHMVNAISNRTAAATACVLWTLVILGTVYLLMESHLCVQGTLSSCESFIMESANGWHDVMFQLEFFLPLTIILFCSVNVVWSLRRRQQLTRQARMRRATRFIMVVASVFITCYLPSVLARLYFLWTVPTSACDPSVHTALHVTLSFTYLNSMLDPLVYYFSSPSLPKFYTKLTICSLKPKRPGRTKTRRSEEMPISNLCSKSSIDGANRSQRPSDGQWDLQVC
UniProt	Q8C131
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL2146354
IUPHAR	311
DrugBank	N/A

Ligand

Name	3,5-DIHYDROXYBENZOIC ACID
Molecular formula	C7H6O4
IUPAC name	3,5-dihydroxybenzoic acid
Molecular weight	154.121
Hydrogen bond acceptor	4
Hydrogen bond donor	3
XlogP	0.9
Synonyms	TRA0063493 3,5-Dihydroxybenzoicacid a-resorcylic acid AJ-20678 BBL019762 CS-W016276 F0001-2331 KS-00000074 NSC-22948 SC-07533 3,5-Dihydroxy benzoic acid Z1705787110 4-10-00-01501 (Beilstein Handbook Reference) AC-1166 alpha-Resorcylic acid Benzoic acid, 3,5-dihydroxy- D0W1OR HY-W015560 MCULE-4631439955 PubChem9162 ST50824444 3,5-Dihydroxybenzoic acid, 97% AE-562/40806860 ANW-13674 DTXSID8059184 InChI=1/C7H6O4/c8-5-1-4(7(10)11)2-6(9)3-5/h1-3,8-9H,(H,10,11 NE10203 RTC-020130 2WC5LMO6L1 TC-020130 UNII-2WC5LMO6L1 3,5-dihyroxybenzoic acid AB00234 AK-44160 BC676294 CTK3I9682 FT-0602267 KSC489M8F NSC22948 SCHEMBL28106 3,5-Dihydroxy-benzoic acid 3,5-Dihydroxybenzoic acid (ACD/Name 4.0) ZINC388546 5-Carboxyresorcinol AC1L1OQD alpha-Resorcylic Acid (3,5-Dihydroxybenzoic Acid) BRN 2207864 D2554 I01-0441 MFCD00002512 Q-200348 STL146349 3,5-Dihydroxybenzoic acid, Vetec(TM) reagent grade, 97% 99-10-5 AI3-52338 B7686 CHEMBL95308 EINECS 202-730-7 KB-28723 NSC 22948 SBB058836 3,5-DHBA TL8006060 UYEMGAFJOZZIFP-UHFFFAOYSA-N 34D AC-10253 AKOS005721135 BDBM50336490 D0570 GTPL5783 LS-143431 PS-4051 ST2410308 3,5-Dihydroxybenzoate, IX 3,5-dihydroxybenzoic acid (alpha-resorcylic acid) ACMC-1BQHO AN-15192 CHEBI:39912 DB-028292 I01-5235 MolPort-001-759-970 RP21800 .alpha.-Resorcylic acid STR02341 [ Show all ]
Inchi Key	UYEMGAFJOZZIFP-UHFFFAOYSA-N
Inchi ID	InChI=1S/C7H6O4/c8-5-1-4(7(10)11)2-6(9)3-5/h1-3,8-9H,(H,10,11)
PubChem CID	7424
ChEMBL	CHEMBL95308
IUPHAR	5783
BindingDB	50336490
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	172000.0 nM	PMID22434674	IUPHAR

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