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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Prostaglandin D2 receptor 2
Species	Mus musculus (Mouse)
Gene	Ptgdr2
Synonym	PGD2 receptor Gpr44 G-protein coupled receptor 44 G protein-coupled receptor 44 DP2 receptor CRTH2 Chemoattractant receptor-homologous molecule expressed on Th2 cells CD294 prostaglandin D2 receptor 2 [ Show all ]
Disease	N/A for non-human GPCRs
Length	382
Amino acid sequence	MANVTLKPLCPLLEEMVQLPNHSNSSLRYIDHVSVLLHGLASLLGLVENGLILFVVGCRMRQTVVTTWVLHLALSDLLAAASLPFFTYFLAVGHSWELGTTFCKLHSSVFFLNMFASGFLLSAISLDRCLQVVRPVWAQNHRTVAVAHRVCLMLWALAVLNTIPYFVFRDTIPRLDGRIMCYYNLLLWNPGPDRDTTCDYRQKALAVSKFLLAFMVPLAIIASSHVAVSLRLHHRGRQRTGRFVRLVAAIVVAFVLCWGPYHIFSLLEARAHSVTTLRQLASRGLPFVTSLAFFNSVVNPLLYVFTCPDMLYKLRRSLRAVLESVLVEDSDQSGGLRNRRRRASSTATPASTLLLADRIPQLRPTRLIGWMRRGSAEVPQRV
UniProt	Q9Z2J6
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL2291
IUPHAR	339
DrugBank	N/A

Ligand

Name	13,14-Dihydro-15-keto-pgd2
Molecular formula	C20H32O5
IUPAC name	(Z)-7-[(1R,2R,5S)-5-hydroxy-3-oxo-2-(3-oxooctyl)cyclopentyl]hept-5-enoic acid
Molecular weight	352.471
Hydrogen bond acceptor	5
Hydrogen bond donor	2
XlogP	2.4
Synonyms	DK-PGD2 SR-01000946246-1 (Z)-7-[(1R,2R,5S)-5-hydroxy-3-oxo-2-(3-oxooctyl)cyclopentyl]hept-5-enoic acid 13,14-dihydro-15-oxo PGD2 59894-07-4 LMFA03010022 13,14-DIHYDRO-15-KETO PROSTAGLANDIN D2 D00GHK Prost-5-en-1-oic acid, 9-hydroxy-11,15-dioxo-, (5Z,9alpha)- 13,14-Dihydro-15-ketoprostaglandin D2 GTPL1900 VSRXYLYXIXYEST-KZTWKYQFSA-N 11,15-dioxo-9S-hydroxy-5Z-prostenoic acid 15-Oxo-13,14-dihydro-PGD2 9.alpha.-Hydroxy-11,15-dioxo-prost-5Z-en-1-oic acid LS-192531 dhk-PGD2 SR-01000946246 (5Z,9alpha)-9-Hydroxy-11,15-dioxoprost-5-en-1-oic acid 13,14-dihydro-15-oxo PGD-2 HMS3648M21 ZINC13887214 1189AH AC1NR1DP Prost-5-en-1-oic acid, 9-hydroxy-11,15-dioxo-, (5Z,9.alpha.)- 13,14-Dihydro-15-keto-prostaglandin D2 [ Show all ]
Inchi Key	VSRXYLYXIXYEST-KZTWKYQFSA-N
Inchi ID	InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,16-18,22H,2-3,5-6,8-14H2,1H3,(H,24,25)/b7-4-/t16-,17-,18+/m1/s1
PubChem CID	5283036
ChEMBL	N/A
IUPHAR	1900
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	19.9526 - 31.6228 nM	PMID12721327, PMID16030019	IUPHAR

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