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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	Lysophosphatidic acid receptor 1
Species	Mus musculus (Mouse)
Gene	Lpar1
Synonym	VZG-1 {ECO:0000303\|PubMed:8922387, ECO:0000303\|PubMed:9600933} Rec1.3 {ECO:0000303\|PubMed:9013780} Lysophosphatidic acid receptor Edg-2 {ECO:0000303\|PubMed:9600933} lysophosphatidic acid receptor Edg-2 Lpar1 LPA1 receptor LPA-1 {ECO:0000303\|PubMed:9600933, ECO:0000303\|PubMed:9721207} LPA receptor 1 {ECO:0000305} LPA receptor 1 GPR26 endothelial differentiation gene 2, lysophosphatidic acid G-protein-coupled receptor, 2 EDG2 VZG1 [ Show all ]
Disease	N/A for non-human GPCRs
Length	364
Amino acid sequence	MAAASTSSPVISQPQFTAMNEQQCFYNESIAFFYNRSGKYLATEWNTVSKLVMGLGITVCVFIMLANLLVMVAIYVNRRFHFPIYYLMANLAAADFFAGLAYFYLMFNTGPNTRRLTVSTWLLRQGLIDTSLTASVANLLAIAIERHITVFRMQLHTRMSNRRVVVVIVVIWTMAIVMGAIPSVGWNCICDIDHCSNMAPLYSDSYLVFWAIFNLVTFVVMVVLYAHIFGYVRQRTMRMSRHSSGPRRNRDTMMSLLKTVVIVLGAFIVCWTPGLVLLLLDVCCPQCDVLAYEKFFLLLAEFNSAMNPIIYSYRDKEMSATFRQILCCQRNENPNGPTEGSDRSASSLNHTILAGVHSNDHSVV
UniProt	P61793
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3621025
IUPHAR	272
DrugBank	N/A

Ligand

Name	lysophosphatidic acid
Molecular formula	C21H41O7P
IUPAC name	(2-hydroxy-3-phosphonooxypropyl) (Z)-octadec-9-enoate
Molecular weight	436.526
Hydrogen bond acceptor	7
Hydrogen bond donor	3
XlogP	5.2
Synonyms	1-Oleyllysophosphatidate 9-octadecenoic acid, 2-hydroxy-3-(phosphonooxy)propyl ester, (9Z)- EINECS 244-710-0 Olein, 1-mono-, 3-phosphate (7CI) [3H]lysophosphatidic acid 1-monooleoylglycerol 3-phosphate 2-Hydroxy-3-(phosphonooxy)propyl oleate cis-9-Octadecenoic acid 2-hydroxy-3-phosphonooxypropyl ester SCHEMBL1548 1-oleoyl-LPA 9-Octadecenoic acid (9Z)-, 2-hydroxy-3-(phosphonooxy)propyl ester (9CI) D0Z9FO Monooleylphosphatidic acid [3H]1-oleoyl-LPA (2-hydroxy-3-phosphonooxypropyl) (Z)-octadec-9-enoate 1-Oleoyl-lysophosphatidate 1-Oleyllysophosphatidic acid AC1NUZKL GTPL2906 Oleoyl lysophosphatidate {2-hydroxy-3-[(9Z)-octadec-9-enoyloxy]propoxy}phosphonic acid 1-Oleoyl-2-lysophosphatidic acid 22002-87-5 CMC_8485 Lysophosphophatidic acid WRGQSWVCFNIUNZ-KTKRTIGZSA-N (2-hydroxy-3-phosphonooxypropyl) (E)-octadec-9-enoate 1-Oleoyl-lyso-phosphatidate 1-oleoyl-lysophosphatidic acid 9-Octadecenoic acid (Z)-, 2-hydroxy-3-(phosphonooxy)propyl ester DTXSID5041061 Olein, 1-mono-, 3-(dihydrogen phosphate) (8CI) [3H]LPA 1-(9Z-octadecenoyl)-phosphatidic acid 2-hydroxy-3-(phosphonooxy)propyl (9Z)-octadec-9-enoate AKOS030561932 GTPL5395 Oleoyl lysophosphatidic acid 1-oleoyl-glycero-3-phosphate D0X0UR monooleylphosphatidate [3H]-LPA (2-hydroxy-3-phosphonooxypropyl) (E)-octadec-9-enoic acid 1-Oleoyl-lyso-phosphatidic acid [ Show all ]
Inchi Key	WRGQSWVCFNIUNZ-KTKRTIGZSA-N
Inchi ID	InChI=1S/C21H41O7P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-21(23)27-18-20(22)19-28-29(24,25)26/h9-10,20,22H,2-8,11-19H2,1H3,(H2,24,25,26)/b10-9-
PubChem CID	5497152
ChEMBL	N/A
IUPHAR	2906
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
EC50	5.0 - 11.7 nM	PMID18781939, PMID8922387, PMID20505096	IUPHAR

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