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GPCR

NameLysophosphatidic acid receptor 1
SpeciesMus musculus (Mouse)
GeneLpar1
SynonymVZG-1 {ECO:0000303|PubMed:8922387, ECO:0000303|PubMed:9600933}
Rec1.3 {ECO:0000303|PubMed:9013780}
Lysophosphatidic acid receptor Edg-2 {ECO:0000303|PubMed:9600933}
lysophosphatidic acid receptor Edg-2
Lpar1
[ Show all ]
DiseaseN/A for non-human GPCRs
Length364
Amino acid sequenceMAAASTSSPVISQPQFTAMNEQQCFYNESIAFFYNRSGKYLATEWNTVSKLVMGLGITVCVFIMLANLLVMVAIYVNRRFHFPIYYLMANLAAADFFAGLAYFYLMFNTGPNTRRLTVSTWLLRQGLIDTSLTASVANLLAIAIERHITVFRMQLHTRMSNRRVVVVIVVIWTMAIVMGAIPSVGWNCICDIDHCSNMAPLYSDSYLVFWAIFNLVTFVVMVVLYAHIFGYVRQRTMRMSRHSSGPRRNRDTMMSLLKTVVIVLGAFIVCWTPGLVLLLLDVCCPQCDVLAYEKFFLLLAEFNSAMNPIIYSYRDKEMSATFRQILCCQRNENPNGPTEGSDRSASSLNHTILAGVHSNDHSVV
UniProtP61793
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL3621025
IUPHAR272
DrugBankN/A

Ligand

Namelysophosphatidic acid
Molecular formulaC21H41O7P
IUPAC name(2-hydroxy-3-phosphonooxypropyl) (Z)-octadec-9-enoate
Molecular weight436.526
Hydrogen bond acceptor7
Hydrogen bond donor3
XlogP5.2
Synonyms1-(9Z-octadecenoyl)-phosphatidic acid
1-oleoyl-lysophosphatidic acid
9-Octadecenoic acid (Z)-, 2-hydroxy-3-(phosphonooxy)propyl ester
DTXSID5041061
Olein, 1-mono-, 3-(dihydrogen phosphate) (8CI)
[ Show all ]
Inchi KeyWRGQSWVCFNIUNZ-KTKRTIGZSA-N
Inchi IDInChI=1S/C21H41O7P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-21(23)27-18-20(22)19-28-29(24,25)26/h9-10,20,22H,2-8,11-19H2,1H3,(H2,24,25,26)/b10-9-
PubChem CID5497152
ChEMBLN/A
IUPHAR2906
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has a partition coefficient log P greater than 5.

Experimental Data

ParameterValueReferenceDatabase source
EC505.0 - 11.7 nMPMID18781939, PMID8922387, PMID20505096IUPHAR

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