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GPCR

NameLysophosphatidic acid receptor 1
SpeciesMus musculus (Mouse)
GeneLpar1
SynonymVZG-1 {ECO:0000303|PubMed:8922387, ECO:0000303|PubMed:9600933}
Rec1.3 {ECO:0000303|PubMed:9013780}
Lysophosphatidic acid receptor Edg-2 {ECO:0000303|PubMed:9600933}
lysophosphatidic acid receptor Edg-2
Lpar1
[ Show all ]
DiseaseN/A for non-human GPCRs
Length364
Amino acid sequenceMAAASTSSPVISQPQFTAMNEQQCFYNESIAFFYNRSGKYLATEWNTVSKLVMGLGITVCVFIMLANLLVMVAIYVNRRFHFPIYYLMANLAAADFFAGLAYFYLMFNTGPNTRRLTVSTWLLRQGLIDTSLTASVANLLAIAIERHITVFRMQLHTRMSNRRVVVVIVVIWTMAIVMGAIPSVGWNCICDIDHCSNMAPLYSDSYLVFWAIFNLVTFVVMVVLYAHIFGYVRQRTMRMSRHSSGPRRNRDTMMSLLKTVVIVLGAFIVCWTPGLVLLLLDVCCPQCDVLAYEKFFLLLAEFNSAMNPIIYSYRDKEMSATFRQILCCQRNENPNGPTEGSDRSASSLNHTILAGVHSNDHSVV
UniProtP61793
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL3621025
IUPHAR272
DrugBankN/A

Ligand

NameAM966
Molecular formulaC27H23ClN2O5
IUPAC name2-[4-[4-[4-[[(1R)-1-(2-chlorophenyl)ethoxy]carbonylamino]-3-methyl-1,2-oxazol-5-yl]phenyl]phenyl]acetic acid
Molecular weight490.94
Hydrogen bond acceptor6
Hydrogen bond donor2
XlogP5.6
Synonyms2917AH
BCP16395
GTPL2905
ZINC65731652
(4'-{4-[(r)-1-(2-chloro-phenyl)-eth-oxycarbonylamino]-3-methyl-isoxazol-5-yl}-biphenyl-4-yl)-acetic acid
[ Show all ]
Inchi KeyWWQTWEWAPUCDDZ-QGZVFWFLSA-N
Inchi IDInChI=1S/C27H23ClN2O5/c1-16-25(29-27(33)34-17(2)22-5-3-4-6-23(22)28)26(35-30-16)21-13-11-20(12-14-21)19-9-7-18(8-10-19)15-24(31)32/h3-14,17H,15H2,1-2H3,(H,29,33)(H,31,32)/t17-/m1/s1
PubChem CID46240292
ChEMBLCHEMBL3621966
IUPHAR2905
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has a partition coefficient log P greater than 5.

Experimental Data

ParameterValueReferenceDatabase source
EC5019.9526 nMPMID20649573IUPHAR

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