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GPCR

NameProkineticin receptor 2
SpeciesHomo sapiens (Human)
GenePROKR2
SynonymPKR2
PK-R2
I5E
GPRg2
GPR73b
[ Show all ]
DiseaseN/A
Length384
Amino acid sequenceMAAQNGNTSFTPNFNPPQDHASSLSFNFSYGDYDLPMDEDEDMTKTRTFFAAKIVIGIALAGIMLVCGIGNFVFIAALTRYKKLRNLTNLLIANLAISDFLVAIICCPFEMDYYVVRQLSWEHGHVLCASVNYLRTVSLYVSTNALLAIAIDRYLAIVHPLKPRMNYQTASFLIALVWMVSILIAIPSAYFATETVLFIVKSQEKIFCGQIWPVDQQLYYKSYFLFIFGVEFVGPVVTMTLCYARISRELWFKAVPGFQTEQIRKRLRCRRKTVLVLMCILTAYVLCWAPFYGFTIVRDFFPTVFVKEKHYLTAFYVVECIAMSNSMINTVCFVTVKNNTMKYFKKMMLLHWRPSQRGSKSSADLDLRTNGVPTTEEVDCIRLK
UniProtQ8NFJ6
Protein Data BankN/A
GPCR-HGmod modelQ8NFJ6
3D structure modelThis predicted structure model is from GPCR-EXP Q8NFJ6.
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL5548
IUPHAR336
DrugBankN/A

Ligand

Nametriazine compound PC10
Molecular formulaC28H27F2N7O4
IUPAC name4-fluoro-N-[N'-[2-[[5-[(4-fluorophenyl)methyl]-1-[(4-methoxyphenyl)methyl]-4,6-dioxo-1,3,5-triazin-2-yl]amino]ethyl]carbamimidoyl]benzamide
Molecular weight563.566
Hydrogen bond acceptor7
Hydrogen bond donor3
XlogP3.3
SynonymsD02VQO
4-fluoro-N-[N'-[2-[[5-[(4-fluorophenyl)methyl]-1-[(4-methoxyphenyl)methyl]-4,6-dioxo-1,3,5-triazin-2-yl]amino]ethyl]carbamimidoyl]benzamide
GTPL6433
Inchi KeyXZNHZFUKGYYVMQ-UHFFFAOYSA-N
Inchi IDInChI=1S/C28H27F2N7O4/c1-41-23-12-4-19(5-13-23)16-36-26(35-27(39)37(28(36)40)17-18-2-8-21(29)9-3-18)33-15-14-32-25(31)34-24(38)20-6-10-22(30)11-7-20/h2-13H,14-17H2,1H3,(H,33,35,39)(H3,31,32,34,38)
PubChem CID73755221
ChEMBLN/A
IUPHAR6433
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand is heavier than 500 daltons.

Experimental Data

ParameterValueReferenceDatabase source
IC501200.0 nMPMID21421710IUPHAR

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