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GPCR

Name12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid receptor
SpeciesMus musculus (Mouse)
GeneGpr31
Synonym12-(S)-HETE acid receptor
HETER1
GPR31
G-protein coupled receptor 31
G protein-coupled receptor 31, D17Leh66c region
[ Show all ]
DiseaseN/A for non-human GPCRs
Length319
Amino acid sequenceMERTNCSAASTVVETAVGTMLTLECVLGLMGNAVALWTFFYRLKVWKPYAVYLFNLVVADLLLATSLPFFAAFYLKGKTWKLGHMPCQVLLFLLAFSRGVGVAFLTTVALDRYLRVVHPRLRVNLLSLRAAWGISSLIWLLMVVLTPQNLLTCRTTQNSTECPSFYPTGGAKAIATCQEVLFFLQVLLPFGLISFCNSGLIRTLQKRLRESDKQPRIRRARVLVAIVLLLFGLCFLPSVLTRVLVHIFQEFKSCSVQQAIVRASDIAGSLTCLHSTLSPAIYCFSNPAFTHSYRKVLKSLRGRRKAAESPSDNLRDSYS
UniProtF8VQN3
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLN/A
IUPHAR98
DrugBankN/A

Ligand

Name12(S)-HETE
Molecular formulaC20H32O3
IUPAC name(5Z,8Z,10E,12S,14Z)-12-hydroxyicosa-5,8,10,14-tetraenoic acid
Molecular weight320.473
Hydrogen bond acceptor3
Hydrogen bond donor2
XlogP5.2
Synonyms(12S)-12-hydroxy-5,8,14-cis-10-trans-eicosatetraenoic acid
12-HYDROXY-5,8,10,14-EICOSATETRAENOIC ACID
D0Z5QA
LMFA03060007
(5Z,8Z,10E,14Z)-(12S)-12-Hydroxyeicosa-5,8,10,14-tetraenoic acid
[ Show all ]
Inchi KeyZNHVWPKMFKADKW-LQWMCKPYSA-N
Inchi IDInChI=1S/C20H32O3/c1-2-3-4-5-10-13-16-19(21)17-14-11-8-6-7-9-12-15-18-20(22)23/h7-11,13-14,17,19,21H,2-6,12,15-16,18H2,1H3,(H,22,23)/b9-7-,11-8-,13-10-,17-14+/t19-/m0/s1
PubChem CID5283155
ChEMBLN/A
IUPHAR5508, 3404
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has a partition coefficient log P greater than 5.

Experimental Data

ParameterValueReferenceDatabase source
EC500.28 nMPMID21712392IUPHAR
Kd4.87 nMPMID21712392IUPHAR

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