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GLASS

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GPCR

Name	D(2) dopamine receptor
Species	Rattus norvegicus (Rat)
Gene	Drd2
Synonym	D2 receptor D2(415) and D₂₍₄₄₄₎ D2A and D_2B D2R Dopamine D2 receptor dopamine receptor 2 [ Show all ]
Disease	N/A for non-human GPCRs
Length	444
Amino acid sequence	MDPLNLSWYDDDLERQNWSRPFNGSEGKADRPHYNYYAMLLTLLIFIIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMIAIVWVLSFTISCPLLFGLNNTDQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRKRRKRVNTKRSSRAFRANLKTPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRMDAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSNPDSPAKPEKNGHAKIVNPRIAKFFEIQTMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFMKILHC
UniProt	P61169
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL339
IUPHAR	215
DrugBank	N/A

Ligand

Name	diazepam
Molecular formula	C16H13ClN2O
IUPAC name	7-chloro-1-methyl-5-phenyl-3H-1,4-benzodiazepin-2-one
Molecular weight	284.743
Hydrogen bond acceptor	2
Hydrogen bond donor	0
XlogP	3.0
Synonyms	WY-3467 SAM001246536 Serenamin Sipam Stesolin Tranimul Umbrium Valium Vazepam AN-23449 Quievita Diazemulus Lamra Anxionil Ro-52807 Diazepam Elmu Mandro-Zep Atilen Diazepamum [INN-Latin] Diazepam Stada Methyldiazepinone (pharmaceutical) Benzopin Dipezona Diazepamu NCGC00178168-01 BRN 0754371 DSSTox_GSID_20406 1-Methyl-5-phenyl-7-chloro-1,3-dihydro-2H-1,4-benzodiazepin-2-one neurolytr il Calmpose e-Pam Novo-Dipam Ceregulart Faustan 7-Chloro-1-methyl-5-3H-1,4-benzodiazepin-2(1H)-one Ortopsique D-Pam GTPL3364 7-Chloro-1-methyl-5-phenyl-2-oxo-2,3-dihydro-1H-benzo[f]-1,4-diazepine Paxum Diacepan I06-0194 AB02310 Pro pam Diastat KBioGR_001012 ZINC6427 Sedapam Setonil Sonacon Tensium Tranquase Usempax ap Valrelease Vivol Diastat, Valium Kratium 2 Ansilive Relanium Diazepam (JP17/USP/INN) Liberetas Apozepam Diazepam Intensol Medipam BCP0726000176 Diazepin Diazepam, European Pharmacopoeia (EP) Reference Standard MLS000759402 Bialzepam Dizac NCGC00178168-04 C06948 Ducene 2H-1, 7-chloro-1,3-dihydro-1-methyl-5-phenyl- Nivalen CC-26451 Eridan 7-chloranyl-1-methyl-5-phenyl-3H-1,4-benzodiazepin-2-one NSC-169897 CHEMBL12 Frustan 7-chloro-1-methyl-5-phenyl-1,3-dihydro-[1,4]benzodiazepin-2-one Paralium D0Y1YC HMS3393N04 7-chloro-1-methyl-5-phenyl-3H-1,4-benzodiazepin-2-one Placidox 5 Dialar InChI=1/C16H13ClN2O/c1-19-14-8-7-12(17)9-13(14)16(18-10-15(19)20)11-5-3-2-4-6-11/h2-9H,10H2,1H AKOS003367969 Q-pam WLN: T67 GNV JN IHJ CG G1 KR S.a. r.l. Seduxen Sico Relax Spectrum5_001890 Tox21_113071_1 Tranquo-tablinen Valiquid Vatran Alupram Quetinil Diazem LA-111 Antenex Ro 5-2805 Diazepam Dak LS-122 Assival Diazepam solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material Methyl diazepinone BDBM50000766 Dipam Diazepam-Lipuro Morosan BRD-K16508793-001-01-8 Drenian Nerozen Calmociteno Duxen 439-14-5 Notense Centrazepam Evacalm 7-chloro-1-methyl-1,3-dihydro-5-phenyl-2H-1,4-benzodiazepin-2-one NSC77518 CPD000058398 Gihitan 7-Chloro-1-methyl-5-phenyl-1H-benzo[e][1,4]diazepin-2(3H)-one Paxate Desconet HSDB 3057 A826456 Pms-Diazepam Diapine KBio1_000967 ZB000640 Saromet Serenzin SMR000058398 STK735517 Trankinon UNII-Q3JTX2Q7TU Valium (TN) Velium Kiatrium An-Ding Radizepam Lembrol Apaurin Ruhsitus Diazepam Fabra Mandrozep Azedipamin Diazepan Diazepam [USAN:INN:BAN:JAN] Methyldiazepinone, pharmaceutical Best [Pharaceutical] Disopam Diazepamu [Polish] NCGC00178168-02 BSPBio_003279 DSSTox_RID_75566 1-Methyl-5-phenyl-7-chloro-1,4-benzodiazepin-2-one Neurolytril CAS-439-14-5 EINECS 207-122-5 53320-84-6 Novodipam CHEBI:49575 Faustan, 7-Chloro-1-methyl-5-phenyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one Paceum D00293 Gubex 7-Chloro-1-methyl-5-phenyl-2H-1,4-benzodiazepin-2-one Placidox 10 Diaceplex Iazepam AC-10561 Prozepam Diastat (TN) W-5055 Zipan Sedipam Sibazon Spectrum3_001780 Tensopam Tranquirit Valaxona Valuzepam Diatran LA 111 Ansiolin Reliver Diazepam 0.1 mg/ml in Methanol Lizan Armonil Diazepam Nordic Mentalium BCP23002 Diazetard Diazepam, United States Pharmacopeia (USP) Reference Standard MLS001424086 BIDD:GT0105 Domalium NCGC00260007-01 Calmaven Duksen 2H-1,4-Benzodiazepin-2-one, 7-chloro-1,3-dihydro-1-methyl-5-phenyl- Nixtensyn CCG-100997 Euphorin P 7-chloro-1,3-dihydro-1-methyl-5-phenyl-2H -1,4-benzodiazepin-2-one NSC-77518 Chuansuan FT-0632135 7-Chloro-1-methyl-5-phenyl-1,4-benzodiazepin-2-one Paranten DB00829 HMS503A15 7-chloro-1-methyl-5-phenyl-3H-1,4-benzodiazepin-2-one. Plidan Diapam Jinpanfan Alboral Q-Pam Relanium Wy 3467 S.A.R.L. Serenack Simasedan Stesolid Tox21_202458 Trazepam Valitran Vazen Amiprol Quiatril Diazemuls La-Iii Anxicalm Ro 5-2807 Diazepam Desitin Mandro Atensine Diazepamum Diazepam solution, 1.0 mg/mL in methanol, analytical standard, for drug analysis Methyldiazepinone Bensedin Dipaz Diazepam-ratiopharm NC00247 Britazepam DSSTox_CID_406 (Z)-7-chloro-1-methyl-5-phenyl-1H-benzo[e][1,4]diazepin-2(3H)-one Nervium Calmod DZP 5-24-04-00300 (Beilstein Handbook Reference) Novazam Cercine Faustal 7-Chloro-1-methyl-2-oxo-5-phenyl-3H-1,4-benzodiazepine Oprea1_126223 CS-0653 Gradual 7-chloro-1-methyl-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-2-one Paxel Desloneg HY-17027 AAOVKJBEBIDNHE-UHFFFAOYSA-N Pomin Diaquel KBio3_002780 Zepaxid SCHEMBL21442 Servizepam Solis T-quil Tranqdyn Unisedil Valium R Vival Diastat Acudial Kratium Anlin Relaminal Diazepam (intranasal, epilepsy) Levium Apo-diazepam Diazepam for system suitability, European Pharmacopoeia (EP) Reference Standard MCULE-8990989144 Baogin Diazepan leo Diazepam [USAN:USP:INN:BAN:JAN] Metil Gobanal Betapam DivK1c_000967 NCGC00178168-03 C-17931 DTXSID4020406 11100-37-1 NINDS_000967 Caudel Elcion CR 7 -chloro-1,3-dihydro-1-methyl-5-phenyl-2H-1,4-benzodiazepin-2-one NSC 169897 Freudal 7-chloro-1-methyl-5-phenyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one Pacitran D07JVL HMS2051N04 7-Chloro-1-methyl-5-phenyl-3H-1,4-benzodiazepin-2(1H)-one Placidox 2 Dialag IDI1_000967 AC1L1EZE Psychopax Winii S.A. R.L Seduksen Sibazone Spectrum4_000576 Tox21_113071 Tranquo-puren Valeo Vanconin Q3JTX2Q7TU Diazapam LA III Ansiolisina Renborin Diazepam 1.0 mg/ml in Methanol Lovium Arzepam Diazepam Rectubes Metamidol BCP9000199 Dienpax Diazepam-Eurogenerics Mono (2-ethylhexyl) phthalate BIDD:PXR0158 Doval Nellium Calmocitene Dupin Noan CCRIS 6009 Eurosan 7-Chloro-1,3-dihydro-1-methyl-5-phenyl-2H-1,4-benzodiazepin-2-one NSC169897 Condition Gewacalm 7-chloro-1-methyl-5-phenyl-1H-1,4-benzodiazepine-2(3H)on Parzam DEA No. 2765 Horizon A3662/0155188 Plumiaz Diapax Kabivitrum Aliseum [ Show all ]
Inchi Key	AAOVKJBEBIDNHE-UHFFFAOYSA-N
Inchi ID	InChI=1S/C16H13ClN2O/c1-19-14-8-7-12(17)9-13(14)16(18-10-15(19)20)11-5-3-2-4-6-11/h2-9H,10H2,1H3
PubChem CID	3016
ChEMBL	CHEMBL12
IUPHAR	3364
BindingDB	50000766
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	<10000.0 nM	PMID6387355	BindingDB

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