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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	D(2) dopamine receptor
Species	Rattus norvegicus (Rat)
Gene	Drd2
Synonym	D2 receptor D2(415) and D₂₍₄₄₄₎ D2A and D_2B D2R Dopamine D2 receptor dopamine receptor 2 [ Show all ]
Disease	N/A for non-human GPCRs
Length	444
Amino acid sequence	MDPLNLSWYDDDLERQNWSRPFNGSEGKADRPHYNYYAMLLTLLIFIIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMIAIVWVLSFTISCPLLFGLNNTDQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRKRRKRVNTKRSSRAFRANLKTPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRMDAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSNPDSPAKPEKNGHAKIVNPRIAKFFEIQTMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFMKILHC
UniProt	P61169
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL339
IUPHAR	215
DrugBank	N/A

Ligand

Name	Opc-4392
Molecular formula	C24H29N3O2
IUPAC name	7-[3-[4-(2,3-dimethylphenyl)piperazin-1-yl]propoxy]-1H-quinolin-2-one
Molecular weight	391.515
Hydrogen bond acceptor	4
Hydrogen bond donor	1
XlogP	4.0
Synonyms	7-[3-[4-(2,3-dimethylphenyl)piperazin-1-yl]propoxy]-1H-quinolin-2-one CHEMBL55171 PDSP1_000687 2(1H)-Quinolinone, 7-(3-(4-(2,3-dimethylphenyl)-1-piperazinyl)propoxy)- AC1L4TPA GTPL268 ZINC5116306 BDBM82065 Opc 4392 7-{3-[4-(2,3-dimethylphenyl)piperazin-1-yl]propoxy}quinolin-2(1h)-one CTK4A7166 PDSP2_000677 2(1H)-Quinolinone, 7-[3-[4-(2,3-dimethylphenyl)-1-piperazinyl]propoxy]- AC1Q6O88 L001306 7-(3-(4-(2,3-Dimethylphenyl)piperazinyl)propoxy)-2(1H)-quinolone CAS_163839 111073-34-8 D09ULA SCHEMBL2424904 2(1H)-Quinolinone,7-[3-[4-(2,3-dimethylphenyl)-1-piperazinyl]propoxy]- ACMC-20dcav NSC_163839 [ Show all ]
Inchi Key	RRLWEQBPSAFVAS-UHFFFAOYSA-N
Inchi ID	InChI=1S/C24H29N3O2/c1-18-5-3-6-23(19(18)2)27-14-12-26(13-15-27)11-4-16-29-21-9-7-20-8-10-24(28)25-22(20)17-21/h3,5-10,17H,4,11-16H2,1-2H3,(H,25,28)
PubChem CID	163839
ChEMBL	N/A
IUPHAR	268
BindingDB	82065
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	3.5 nM	PMID10327430	BindingDB
Ki	5.8 nM	PMID3130534	BindingDB
Ki	9.8 nM	PMID7616416	BindingDB
Ki	18.0 nM	PMID7616416	BindingDB
Ki	19.8 nM	PMID7616416	BindingDB
Ki	88.0 nM	PMID10327430	BindingDB
Ki	90.9 nM	PMID10327430	BindingDB

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