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GPCR

NameMetabotropic glutamate receptor 7
SpeciesHomo sapiens (Human)
GeneGRM7
SynonymGLUR7
glutamate receptor
GPRC1G
mGlu7 receptor
mGlu7a receptor
[ Show all ]
DiseaseN/A
Length915
Amino acid sequenceMVQLRKLLRVLTLMKFPCCVLEVLLCALAAAARGQEMYAPHSIRIEGDVTLGGLFPVHAKGPSGVPCGDIKRENGIHRLEAMLYALDQINSDPNLLPNVTLGARILDTCSRDTYALEQSLTFVQALIQKDTSDVRCTNGEPPVFVKPEKVVGVIGASGSSVSIMVANILRLFQIPQISYASTAPELSDDRRYDFFSRVVPPDSFQAQAMVDIVKALGWNYVSTLASEGSYGEKGVESFTQISKEAGGLCIAQSVRIPQERKDRTIDFDRIIKQLLDTPNSRAVVIFANDEDIKQILAAAKRADQVGHFLWVGSDSWGSKINPLHQHEDIAEGAITIQPKRATVEGFDAYFTSRTLENNRRNVWFAEYWEENFNCKLTISGSKKEDTDRKCTGQERIGKDSNYEQEGKVQFVIDAVYAMAHALHHMNKDLCADYRGVCPEMEQAGGKKLLKYIRNVNFNGSAGTPVMFNKNGDAPGRYDIFQYQTTNTSNPGYRLIGQWTDELQLNIEDMQWGKGVREIPASVCTLPCKPGQRKKTQKGTPCCWTCEPCDGYQYQFDEMTCQHCPYDQRPNENRTGCQDIPIIKLEWHSPWAVIPVFLAMLGIIATIFVMATFIRYNDTPIVRASGRELSYVLLTGIFLCYIITFLMIAKPDVAVCSFRRVFLGLGMCISYAALLTKTNRIYRIFEQGKKSVTAPRLISPTSQLAITSSLISVQLLGVFIWFGVDPPNIIIDYDEHKTMNPEQARGVLKCDITDLQIICSLGYSILLMVTCTVYAIKTRGVPENFNEAKPIGFTMYTTCIVWLAFIPIFFGTAQSAEKLYIQTTTLTISMNLSASVALGMLYMPKVYIIIFHPELNVQKRKRSFKAVVTAATMSSRLSHKPSDRPNGEAKTELCENVDPNSPAAKKKYVSYNNLVI
UniProtQ14831
Protein Data Bank5c5c, 3mq4
GPCR-HGmod modelN/A
3D structure modelThis structure is from PDB ID 5c5c.
BioLiPBL0319784,BL0319785,BL0319786,, BL0181059, BL0181060, BL0319782,BL0319783
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL3777
IUPHAR295
DrugBankBE0000834

Ligand

NameCHEMBL1830707
Molecular formulaC14H13N5S
IUPAC nameN-pyridin-2-yl-5-thia-3,11,12-triazatricyclo[8.3.0.02,6]trideca-1(10),2(6),3,12-tetraen-4-amine
Molecular weight283.353
Hydrogen bond acceptor5
Hydrogen bond donor2
XlogP2.8
SynonymsZINC72118775
4,5,6,8-Tetrahydro-N-2-pyridinylpyrazolo[3',4':6,7]cyclohepta[1,2]thiazol-2-amine
compound 22a [PMID: 21688779]
AKOS024458120
MolPort-023-277-166
[ Show all ]
Inchi KeyDBISXWCOHGUFSF-UHFFFAOYSA-N
Inchi IDInChI=1S/C14H13N5S/c1-2-7-15-12(6-1)17-14-18-13-9-8-16-19-10(9)4-3-5-11(13)20-14/h1-2,6-8H,3-5H2,(H,16,19)(H,15,17,18)
PubChem CID46836562
ChEMBLCHEMBL1830707
IUPHAR6231
BindingDB50353290
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
EC50<10000.0 nMPMID21688779BindingDB,ChEMBL
IC50<10000.0 nMPMID21688779BindingDB,ChEMBL

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