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GPCR

Name	Cannabinoid receptor 2
Species	Homo sapiens (Human)
Gene	CNR2
Synonym	Peripheral cannabinoid receptor rCB2 hCB2 cannabinoid receptor 2 (macrophage) cannabinoid receptor 2 (spleen) CB-2 CB2 CB2 receptor CB2-R CX5 [ Show all ]
Disease	Immune disorder Inflammatory bowel disease Inflammatory disease Neuropathic pain Osteoporosis Pain Atopic dermatitis Rheumatoid arthritis [ Show all ]
Length	360
Amino acid sequence	MEECWVTEIANGSKDGLDSNPMKDYMILSGPQKTAVAVLCTLLGLLSALENVAVLYLILSSHQLRRKPSYLFIGSLAGADFLASVVFACSFVNFHVFHGVDSKAVFLLKIGSVTMTFTASVGSLLLTAIDRYLCLRYPPSYKALLTRGRALVTLGIMWVLSALVSYLPLMGWTCCPRPCSELFPLIPNDYLLSWLLFIAFLFSGIIYTYGHVLWKAHQHVASLSGHQDRQVPGMARMRLDVRLAKTLGLVLAVLLICWFPVLALMAHSLATTLSDQVKKAFAFCSMLCLINSMVNPVIYALRSGEIRSSAHHCLAHWKKCVRGLGSEAKEEAPRSSVTETEADGKITPWPDSRDLDLSDC
UniProt	P34972
Protein Data Bank	5zty
GPCR-HGmod model	P34972
3D structure model	This structure is from PDB ID 5zty.
BioLiP	BL0438927
Therapeutic Target Database	T37693
ChEMBL	CHEMBL253
IUPHAR	57
DrugBank	BE0000095

Ligand

Name	5-ethoxy-2-(5-methyl-4-phenyl-1H-pyrazol-3-yl)phenol
Molecular formula	C18H18N2O2
IUPAC name	5-ethoxy-2-(5-methyl-4-phenyl-1H-pyrazol-3-yl)phenol
Molecular weight	294.354
Hydrogen bond acceptor	3
Hydrogen bond donor	2
XlogP	3.9
Synonyms	AKOS001631787 MCULE-9359353820 ST50475647 5-ethoxy-2-(3-methyl-4-phenyl-1H-pyrazol-5-yl)phenol CCG-107430 MolPort-001-818-969 (6Z)-3-ethoxy-6-(5-methyl-4-phenyl-1,2-dihydropyrazol-3-ylidene)-1-cyclohexa-2,4-dienone AC1OA0V4 cid_5407922 SR-01000444003 3-ethoxy-6-(5-methyl-4-phenyl-1,2-dihydropyrazol-3-ylidene)cyclohexa-2,4-dien-1-one AKOS005628029 MLS-0437220.0001 STK847813 AB00115424-01 Oprea1_270135 (6Z)-3-ethoxy-6-(5-methyl-4-phenyl-1,2-dihydropyrazol-3-ylidene)cyclohexa-2,4-dien-1-one AC1Q364C F0758-0082 SR-01000444003-1 394237-72-0 5-ethoxy-2-(5-methyl-4-phenylpyrazol-3-yl)phenol BDBM76081 MolPort-000-812-881 ZINC5123817 AC1NTNSC CHEMBL1708243 Oprea1_697527 (6Z)-3-ethoxy-6-(5-methyl-4-phenyl-3-pyrazolin-3-ylidene)cyclohexa-2,4-dien-1-one [ Show all ]
Inchi Key	ARZWFJWBGYWQHV-UHFFFAOYSA-N
Inchi ID	InChI=1S/C18H18N2O2/c1-3-22-14-9-10-15(16(21)11-14)18-17(12(2)19-20-18)13-7-5-4-6-8-13/h4-11,21H,3H2,1-2H3,(H,19,20)
PubChem CID	797608
ChEMBL	CHEMBL1708243
IUPHAR	N/A
BindingDB	76081
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	<32000.0 nM	, PubChem BioAssay data set	BindingDB,ChEMBL
IC50	23800.0 nM	, PubChem BioAssay data set	BindingDB,ChEMBL

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