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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Type-1 angiotensin II receptor
Species	Homo sapiens (Human)
Gene	AGTR1
Synonym	Type-1 angiotensin II receptor HAT1R Agtr-1a type-1A angiotensin II receptor AT1 type-1B angiotensin II receptor vascular type-1 angiotensin II receptor AT3 AT2R1A AG2S Agtr-1b Agtr1 angiotensin II receptor angiotensin II receptor, type 1 angiotensin II receptor, type 1a angiotensin II receptor, type 1b angiotensin II type-1 receptor angiotensin II type-1A receptor AT2R1 AT1BR AT1AR AT1 receptor Angtr-1b Angtr-1a angiotensin II type-1B receptor [ Show all ]
Disease	Metabolic syndrome x Myocardial infarction Hypertension Restenosis Alzheimer disease High blood pressure Heart failure Unspecified Hypotension [ Show all ]
Length	359
Amino acid sequence	MILNSSTEDGIKRIQDDCPKAGRHNYIFVMIPTLYSIIFVVGIFGNSLVVIVIYFYMKLKTVASVFLLNLALADLCFLLTLPLWAVYTAMEYRWPFGNYLCKIASASVSFNLYASVFLLTCLSIDRYLAIVHPMKSRLRRTMLVAKVTCIIIWLLAGLASLPAIIHRNVFFIENTNITVCAFHYESQNSTLPIGLGLTKNILGFLFPFLIILTSYTLIWKALKKAYEIQKNKPRNDDIFKIIMAIVLFFFFSWIPHQIFTFLDVLIQLGIIRDCRIADIVDTAMPITICIAYFNNCLNPLFYGFLGKKFKRYFLQLLKYIPPKAKSHSNLSTKMSTLSYRPSDNVSSSTKKPAPCFEVE
UniProt	P30556
Protein Data Bank	6do1, 4zud, 4yay
GPCR-HGmod model	P30556
3D structure model	This structure is from PDB ID 6do1.
BioLiP	BL0312790, BL0326733, BL0439004,BL0439005
Therapeutic Target Database	T74456
ChEMBL	CHEMBL227
IUPHAR	34
DrugBank	BE0000062

Ligand

Name	MLS000058898
Molecular formula	C13H22N2O2S
IUPAC name	3-butan-2-yl-5-ethyl-6-hydroxy-2-propylsulfanylpyrimidin-4-one
Molecular weight	270.391
Hydrogen bond acceptor	4
Hydrogen bond donor	1
XlogP	3.3
Synonyms	3-sec-butyl-5-ethyl-6-hydroxy-2-(propylthio)-4(3H)-pyrimidinone MolPort-002-113-936 AB00081660-01 HMS1582N07 1-butan-2-yl-5-ethyl-6-hydroxy-2-propylsulfanylpyrimidin-4-one Cambridge id 5344703 MLS-0014564.0001 5-ethyl-6-hydroxy-2-(propylthio)-1-sec-butyl-pyrimidin-4-one CHEMBL1329339 Oprea1_738097 AC1MDT7W HMS2444A13 1-butan-2-yl-5-ethyl-6-oxidanyl-2-propylsulfanyl-pyrimidin-4-one CHEBI:113003 cid_2842565 SMR000069467 1-butan-2-yl-5-ethyl-6-hydroxy-2-(propylthio)-4-pyrimidinone BDBM76107 MCULE-7914868370 [ Show all ]
Inchi Key	BKSVBBOOWFNSIG-UHFFFAOYSA-N
Inchi ID	InChI=1S/C13H22N2O2S/c1-5-8-18-13-14-11(16)10(7-3)12(17)15(13)9(4)6-2/h9,16H,5-8H2,1-4H3
PubChem CID	135458801
ChEMBL	CHEMBL1329339
IUPHAR	N/A
BindingDB	76107
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	<100000.0 nM	, PubChem BioAssay data set	BindingDB,ChEMBL

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