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GPCR

NamePlatelet-activating factor receptor
SpeciesCavia porcellus (Guinea pig)
GenePTAFR
SynonymPAF-R
PAFr
DiseaseN/A for non-human GPCRs
Length342
Amino acid sequenceMELNSSSRVDSEFRYTLFPIVYSIIFVLGIIANGYVLWVFARLYPSKKLNEIKIFMVNLTVADLLFLITLPLWIVYYSNQGNWFLPKFLCNLAGCLFFINTYCSVAFLGVITYNRFQAVKYPIKTAQATTRKRGIALSLVIWVAIVAAASYFLVMDSTNVVSNKAGSGNITRCFEHYEKGSKPVLIIHICIVLGFFIVFLLILFCNLVIIHTLLRQPVKQQRNAEVRRRALWMVCTVLAVFVICFVPHHMVQLPWTLAELGMWPSSNHQAINDAHQVTLCLLSTNCVLDPVIYCFLTKKFRKHLSEKLNIMRSSQKCSRVTTDTGTEMAIPINHTPVNPIKN
UniProtP21556
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL5136
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL325928
Molecular formulaC21H19N7O
IUPAC name1,3-dimethyl-5-[4-(2-methylimidazo[4,5-c]pyridin-1-yl)phenyl]-6,8-dihydropyrazolo[3,4-b][1,4]diazepin-7-one
Molecular weight385.431
Hydrogen bond acceptor5
Hydrogen bond donor1
XlogP2.0
SynonymsBDBM50033262
SCHEMBL9386010
1,3-Dimethyl-5-[4-(2-methyl-imidazo[4,5-c]pyridin-1-yl)-phenyl]-6,8-dihydro-1H-pyrazolo[3,4-b][1,4]diazepin-7-one
1,3-Dimethyl-5-[4-(2-methyl-1H-imidazo[4,5-c]pyridin-1-yl)phenyl]-6,8-dihydropyrazolo[3,4-b][1,4]diazepin-7(1H)-one
Inchi KeyBNIQTMIZFAHZET-UHFFFAOYSA-N
Inchi IDInChI=1S/C21H19N7O/c1-12-20-21(27(3)26-12)25-19(29)10-16(24-20)14-4-6-15(7-5-14)28-13(2)23-17-11-22-9-8-18(17)28/h4-9,11H,10H2,1-3H3,(H,25,29)
PubChem CID135492593
ChEMBLCHEMBL325928
IUPHARN/A
BindingDB50033262
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
IC5026.0 nMPMID7658439BindingDB,ChEMBL

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