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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Trace amine-associated receptor 1
Species	Rattus norvegicus (Rat)
Gene	Taar1
Synonym	TA1 receptor TaR-1 TAR1 Trace amine receptor 1 TRAR1
Disease	N/A for non-human GPCRs
Length	332
Amino acid sequence	MHLCHNSANISHTNSNWSRDVRASLYSLISLIILTTLVGNLIVIISISHFKQLHTPTNWLLHSMAVVDFLLGCLVMPYSMVRTVEHCWYFGELFCKLHTSTDIMLSSASILHLAFISIDRYYAVCDPLRYKAKINLAAIFVMILISWSLPAVFAFGMIFLELNLEGVEELYHNQVFCLRGCFPFFSKVSGVLAFMTSFYIPGSVMLFVYYRIYFIAKGQARSINRANLQVGLEGESRAPQSKETKAAKTLGIMVGVFLLCWCPFFFCMVLDPFLGYVIPPTLNDTLNWFGYLNSAFNPMVYAFFYPWFRRALKMVLFGKIFQKDSSRSKLFL
UniProt	Q923Y9
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3833
IUPHAR	364
DrugBank	N/A

Ligand

Name	SCHEMBL15578660
Molecular formula	C21H23N5O3
IUPAC name	1-(6-ethoxypyridin-2-yl)-N-[4-[(2S)-morpholin-2-yl]phenyl]pyrazole-4-carboxamide
Molecular weight	393.447
Hydrogen bond acceptor	6
Hydrogen bond donor	2
XlogP	1.7
Synonyms	US9487501, 28 BDBM256427
Inchi Key	BOJQVQWGSQTWRG-GOSISDBHSA-N
Inchi ID	InChI=1S/C21H23N5O3/c1-2-28-20-5-3-4-19(25-20)26-14-16(12-23-26)21(27)24-17-8-6-15(7-9-17)18-13-22-10-11-29-18/h3-9,12,14,18,22H,2,10-11,13H2,1H3,(H,24,27)/t18-/m1/s1
PubChem CID	73442392
ChEMBL	N/A
IUPHAR	N/A
BindingDB	256427
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	2.2 nM	N/A	BindingDB

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