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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	5-hydroxytryptamine receptor 4
Species	Cavia porcellus (Guinea pig)
Gene	HTR4
Synonym	5-HT-4 5-HT4 Serotonin receptor 4
Disease	N/A for non-human GPCRs
Length	388
Amino acid sequence	MDKLDANVSSKEGFGSVEKVVLLTFLSAVILMAILGNLLVMVAVCRDRQLRKIKTNYFIVSLAFADLLVSVLVMPFGAIELVQDIWVYGEMFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNKMTPLRIALMLGGCWVIPMFISFLPIMQGWNNIGIVDLIEKRKFNQNSNSTYCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHARQIQVLQRAGAPAEGRPQPADQHSTHRMRTETKAAKTLCIIMGCFCLCWAPFFVTNIVDPFIDYTVPGQLWTAFLWLGYINSGLNPFLYAFLNKSFRRAFLIILCCDDERYRRPSILGQTVPCSTTTINGSTHVLRDTVECGGQWESQCHPAASSPLVAAQPIDT
UniProt	O70528
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL5017
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	CHEMBL77642
Molecular formula	C15H22N6O
IUPAC name	1-[(E)-(5-methoxy-2H-indazol-3-yl)methylideneamino]-2-pentylguanidine
Molecular weight	302.382
Hydrogen bond acceptor	4
Hydrogen bond donor	3
XlogP	2.4
Synonyms	N/A
Inchi Key	BVNHPTDEYQDPMU-VCHYOVAHSA-N
Inchi ID	InChI=1S/C15H22N6O/c1-3-4-5-8-17-15(16)21-18-10-14-12-9-11(22-2)6-7-13(12)19-20-14/h6-7,9-10H,3-5,8H2,1-2H3,(H,19,20)(H3,16,17,21)/b18-10+
PubChem CID	135458020
ChEMBL	CHEMBL77642
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
pD2	>4.0 -	PMID7608899	ChEMBL
Relative efficacy	0.0 -	PMID7608899	ChEMBL

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