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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Vasopressin V2 receptor
Species	Rattus norvegicus (Rat)
Gene	Avpr2
Synonym	AVPR V2 Antidiuretic hormone receptor ADHR Renal-type arginine vasopressin receptor V2 receptor V2R DIR3 [ Show all ]
Disease	N/A for non-human GPCRs
Length	371
Amino acid sequence	MLLVSTVSAVPGLFSPPSSPSNSSQEELLDDRDPLLVRAELALLSTIFVAVALSNGLVLGALIRRGRRGRWAPMHVFISHLCLADLAVALFQVLPQLAWDATDRFHGPDALCRAVKYLQMVGMYASSYMILAMTLDRHRAICRPMLAYRHGGGARWNRPVLVAWAFSLLLSLPQLFIFAQRDVGNGSGVFDCWARFAEPWGLRAYVTWIALMVFVAPALGIAACQVLIFREIHASLVPGPSERAGRRRRGRRTGSPSEGAHVSAAMAKTVRMTLVIVIVYVLCWAPFFLVQLWAAWDPEAPLERPPFVLLMLLASLNSCTNPWIYASFSSSVSSELRSLLCCAQRHTTHSLGPQDESCATASSSLMKDTPS
UniProt	Q00788
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3766
IUPHAR	368
DrugBank	N/A

Ligand

Name	CHEMBL338503
Molecular formula	C30H40N2O6S
IUPAC name	3-[1-[(1S,2S,4R)-7,7-dimethyl-1-(spiro[1,2-dihydroindene-3,4'-piperidine]-1'-ylsulfonylmethyl)-2-bicyclo[2.2.1]heptanyl]-2,5-dioxopyrrolidin-3-yl]propanoic acid
Molecular weight	556.718
Hydrogen bond acceptor	7
Hydrogen bond donor	1
XlogP	3.6
Synonyms	3-{1-[7,7-dimethyl-1-spiro[2,3-dihydro-1H-indene-1,4''-(hexahydropyridine)]-1-ylsulfonylmethyl-(1S,2S,4R)-bicyclo[2.2.1]hept-2-yl]-2,5-dioxotetrahydro-1H-3-pyrrolyl}propanoic acid BDBM50043095
Inchi Key	DBPQXDYXFWSSCU-WKBYALOHSA-N
Inchi ID	InChI=1S/C30H40N2O6S/c1-28(2)22-10-12-30(28,24(18-22)32-25(33)17-21(27(32)36)7-8-26(34)35)19-39(37,38)31-15-13-29(14-16-31)11-9-20-5-3-4-6-23(20)29/h3-6,21-22,24H,7-19H2,1-2H3,(H,34,35)/t21?,22-,24+,30-/m1/s1
PubChem CID	11757440
ChEMBL	CHEMBL338503
IUPHAR	N/A
BindingDB	50043095
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand is heavier than 500 daltons.

Experimental Data

Parameter	Value	Reference	Database source
IC50	6600.0 nM	PMID8258821	BindingDB,ChEMBL

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