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GPCR

NameCysteinyl leukotriene receptor 1
SpeciesCavia porcellus (Guinea pig)
GeneCYSLTR1
SynonymCysLTR1
Cysteinyl leukotriene D4 receptor
LTD4 receptor
DiseaseN/A for non-human GPCRs
Length340
Amino acid sequenceMDETGNPTIPPASNNTCYDSIDDFRNQVYSTLYSMISVVGFFGNGFVLYVLVKTYHEKSAFQVYMINLAVADLLCVCTLPLRVAYYVHKGIWLFGDFLCRLSTYALYVNLYCSIFFMTAMSFFRCVAIVFPVQNISLVTQKKARLVCIAIWMFVILTSSPFLMANTYKDEKNNTKCFEPPQDNQAKNYVLILHYVSLFIGFIIPFITIIVCYTMIIFTLLKSSMKKNLSSRKRAIGMIIVVTAAFLVSFMPYHIQRTIHLHFLHNKTKPCDSILRMQKSVVITLSLAASNCCFDPLLYFFSGGNFRRRLSTIRKYSLSSMTYIPKKKTSLPQKGKDICKE
UniProtQ2NNR5
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL5645
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL19085
Molecular formulaC21H24N8O
IUPAC name5-[4-(4-phenylbutoxy)phenyl]-2-[3-(2H-tetrazol-5-yl)propyl]tetrazole
Molecular weight404.478
Hydrogen bond acceptor7
Hydrogen bond donor1
XlogP4.3
SynonymsN/A
Inchi KeyDBQKUKQXLAVMLR-UHFFFAOYSA-N
Inchi IDInChI=1S/C21H24N8O/c1-2-7-17(8-3-1)9-4-5-16-30-19-13-11-18(12-14-19)21-24-28-29(25-21)15-6-10-20-22-26-27-23-20/h1-3,7-8,11-14H,4-6,9-10,15-16H2,(H,22,23,26,27)
PubChem CID44272351
ChEMBLCHEMBL19085
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
pKB6.86 -PMID1313876ChEMBL

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