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GPCR

NameHistamine H3 receptor
SpeciesMus musculus (Mouse)
GeneHrh3
SynonymGPCR97
H3 receptor
H3R
HH3R
DiseaseN/A for non-human GPCRs
Length445
Amino acid sequenceMERAPPDGLMNASGALAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFVADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCASSVFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMALVWVLAFLLYGPAILSWEYLSGGSSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGGREAGPEPPPDAQPSPPPAPPSCWGCWPKGHGEAMPLHRYGVGEAGPGVETGEAGLGGGSGGGAAASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSITQRFRLSRDKKVAKSLAIIVSIFGLCWAPYTLLMIIRAACHGHCVPDYWYETSFWLLWANSAVNPVLYPLCHYSFRRAFTKLLCPQKLKVQPHGSLEQCWK
UniProtP58406
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL3263
IUPHAR264
DrugBankN/A

Ligand

NameCHEMBL16593
Molecular formulaC13H21N3O2
IUPAC name3-(1H-imidazol-5-yl)propyl N-cyclohexylcarbamate
Molecular weight251.33
Hydrogen bond acceptor3
Hydrogen bond donor2
XlogP2.2
SynonymsN-Cyclohexylcarbamic acid 3-(1H-imidazol-4-yl)propyl ester
SCHEMBL7977480
BDBM50051182
Cyclohexyl-carbamic acid 3-(1H-imidazol-4-yl)-propyl ester
Inchi KeyDBSAHPKGLBUUAT-UHFFFAOYSA-N
Inchi IDInChI=1S/C13H21N3O2/c17-13(16-11-5-2-1-3-6-11)18-8-4-7-12-9-14-10-15-12/h9-11H,1-8H2,(H,14,15)(H,16,17)
PubChem CID10610770
ChEMBLCHEMBL16593
IUPHARN/A
BindingDB50051182
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
ED50<10.0 mg.kg-1PMID8676353ChEMBL

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