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GPCR

NameCysteinyl leukotriene receptor 2
SpeciesHomo sapiens (Human)
GeneCYSLTR2
SynonymCysLTR2
CysLT2 receptor
LTC4
HPN321
hGPCR21
[ Show all ]
DiseaseUnspecified
Asthma
Length346
Amino acid sequenceMERKFMSLQPSISVSEMEPNGTFSNNNSRNCTIENFKREFFPIVYLIIFFWGVLGNGLSIYVFLQPYKKSTSVNVFMLNLAISDLLFISTLPFRADYYLRGSNWIFGDLACRIMSYSLYVNMYSSIYFLTVLSVVRFLAMVHPFRLLHVTSIRSAWILCGIIWILIMASSIMLLDSGSEQNGSVTSCLELNLYKIAKLQTMNYIALVVGCLLPFFTLSICYLLIIRVLLKVEVPESGLRVSHRKALTTIIITLIIFFLCFLPYHTLRTVHLTTWKVGLCKDRLHKALVITLALAAANACFNPLLYYFAGENFKDRLKSALRKGHPQKAKTKCVFPVSVWLRKETRV
UniProtQ9NS75
Protein Data BankN/A
GPCR-HGmod modelQ9NS75
3D structure modelThis predicted structure model is from GPCR-EXP Q9NS75.
BioLiPN/A
Therapeutic Target DatabaseT74238
ChEMBLCHEMBL4330
IUPHAR270
DrugBankBE0000099

Ligand

NameCHEMBL2413379
Molecular formulaC30H38O7
IUPAC name4-(carboxymethoxy)-3-[(E)-3-(3-dodecoxyphenyl)prop-2-enoyl]benzoic acid
Molecular weight510.627
Hydrogen bond acceptor7
Hydrogen bond donor2
XlogP8.3
SynonymsN/A
Inchi KeyDBSKFJPBQIDDDV-BMRADRMJSA-N
Inchi IDInChI=1S/C30H38O7/c1-2-3-4-5-6-7-8-9-10-11-19-36-25-14-12-13-23(20-25)15-17-27(31)26-21-24(30(34)35)16-18-28(26)37-22-29(32)33/h12-18,20-21H,2-11,19,22H2,1H3,(H,32,33)(H,34,35)/b17-15+
PubChem CID71654672
ChEMBLCHEMBL2413379
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand is heavier than 500 daltons.
This ligand has a partition coefficient log P greater than 5.

Experimental Data

ParameterValueReferenceDatabase source
IC50250.0 nMPMID23455026ChEMBL
Imax80.5 %PMID23455026ChEMBL
Inhibition70.5 %PMID23455026ChEMBL

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