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Name | Platelet-activating factor receptor |
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Species | Homo sapiens (Human) |
Gene | PTAFR |
Synonym | PAFr PAF-R PAF receptor AGEPC receptor |
Disease | Nerve injury Ocular allergy Pain Unspecified Psoriasis [ Show all ] |
Length | 342 |
Amino acid sequence | MEPHDSSHMDSEFRYTLFPIVYSIIFVLGVIANGYVLWVFARLYPCKKFNEIKIFMVNLTMADMLFLITLPLWIVYYQNQGNWILPKFLCNVAGCLFFINTYCSVAFLGVITYNRFQAVTRPIKTAQANTRKRGISLSLVIWVAIVGAASYFLILDSTNTVPDSAGSGNVTRCFEHYEKGSVPVLIIHIFIVFSFFLVFLIILFCNLVIIRTLLMQPVQQQRNAEVKRRALWMVCTVLAVFIICFVPHHVVQLPWTLAELGFQDSKFHQAINDAHQVTLCLLSTNCVLDPVIYCFLTKKFRKHLTEKFYSMRSSRKCSRATTDTVTEVVVPFNQIPGNSLKN |
UniProt | P25105 |
Protein Data Bank | 5zkq, 5zkp |
GPCR-HGmod model | P25105 |
3D structure model | This structure is from PDB ID 5zkq. |
BioLiP | BL0417415, BL0417417,BL0417419, BL0417416,BL0417418, BL0417414 |
Therapeutic Target Database | T87023 |
ChEMBL | CHEMBL250 |
IUPHAR | 334 |
DrugBank | BE0005561 |
Name | CHEMBL142433 |
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Molecular formula | C26H28N4O2 |
IUPAC name | 11-oxo-2-propan-2-yl-N-[(2R)-5-pyridin-3-ylpentan-2-yl]pyrido[2,1-b]quinazoline-8-carboxamide |
Molecular weight | 428.536 |
Hydrogen bond acceptor | 4 |
Hydrogen bond donor | 1 |
XlogP | 3.7 |
Synonyms | BDBM50023324 2-Isopropyl-11-oxo-11H-pyrido[2,1-b]quinazoline-8-carboxylic acid (1-methyl-4-pyridin-3-yl-butyl)-amide |
Inchi Key | DCNXKPFVMNEKDU-GOSISDBHSA-N |
Inchi ID | InChI=1S/C26H28N4O2/c1-17(2)20-9-11-23-22(14-20)26(32)30-16-21(10-12-24(30)29-23)25(31)28-18(3)6-4-7-19-8-5-13-27-15-19/h5,8-18H,4,6-7H2,1-3H3,(H,28,31)/t18-/m1/s1 |
PubChem CID | 13557506 |
ChEMBL | CHEMBL142433 |
IUPHAR | N/A |
BindingDB | 50023324 |
DrugBank | N/A |
Structure | ![]() |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
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IC50 | 600.0 nM | PMID3339617 | BindingDB,ChEMBL |
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