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GPCR

NamePlatelet-activating factor receptor
SpeciesHomo sapiens (Human)
GenePTAFR
SynonymPAFr
PAF-R
PAF receptor
AGEPC receptor
DiseaseNerve injury
Ocular allergy
Pain
Unspecified
Psoriasis
[ Show all ]
Length342
Amino acid sequenceMEPHDSSHMDSEFRYTLFPIVYSIIFVLGVIANGYVLWVFARLYPCKKFNEIKIFMVNLTMADMLFLITLPLWIVYYQNQGNWILPKFLCNVAGCLFFINTYCSVAFLGVITYNRFQAVTRPIKTAQANTRKRGISLSLVIWVAIVGAASYFLILDSTNTVPDSAGSGNVTRCFEHYEKGSVPVLIIHIFIVFSFFLVFLIILFCNLVIIRTLLMQPVQQQRNAEVKRRALWMVCTVLAVFIICFVPHHVVQLPWTLAELGFQDSKFHQAINDAHQVTLCLLSTNCVLDPVIYCFLTKKFRKHLTEKFYSMRSSRKCSRATTDTVTEVVVPFNQIPGNSLKN
UniProtP25105
Protein Data Bank5zkq, 5zkp
GPCR-HGmod modelP25105
3D structure modelThis structure is from PDB ID 5zkq.
BioLiPBL0417415, BL0417417,BL0417419, BL0417416,BL0417418, BL0417414
Therapeutic Target DatabaseT87023
ChEMBLCHEMBL250
IUPHAR334
DrugBankBE0005561

Ligand

NameCHEMBL57825
Molecular formulaC26H28N4O2
IUPAC name11-oxo-2-propan-2-yl-N-(5-pyridin-3-ylpentan-2-yl)pyrido[2,1-b]quinazoline-8-carboxamide
Molecular weight428.536
Hydrogen bond acceptor4
Hydrogen bond donor1
XlogP3.7
SynonymsBDBM50019687
SCHEMBL11010123
Inchi KeyDCNXKPFVMNEKDU-UHFFFAOYSA-N
Inchi IDInChI=1S/C26H28N4O2/c1-17(2)20-9-11-23-22(14-20)26(32)30-16-21(10-12-24(30)29-23)25(31)28-18(3)6-4-7-19-8-5-13-27-15-19/h5,8-18H,4,6-7H2,1-3H3,(H,28,31)
PubChem CID13557504
ChEMBLCHEMBL57825
IUPHARN/A
BindingDB50019687
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
IC50250.0 nMPMID3339617BindingDB,ChEMBL

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