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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Histamine H4 receptor
Species	Homo sapiens (Human)
Gene	HRH4
Synonym	Pfi-013 SP9144 HH4R H4R H4 receptor GPRv53 GPCR105 G-protein coupled receptor 105 AXOR35 [ Show all ]
Disease	Allergic rhinitis Asthma Inflammatory disease Rheumatoid arthritis
Length	390
Amino acid sequence	MPDTNSTINLSLSTRVTLAFFMSLVAFAIMLGNALVILAFVVDKNLRHRSSYFFLNLAISDFFVGVISIPLYIPHTLFEWDFGKEICVFWLTTDYLLCTASVYNIVLISYDRYLSVSNAVSYRTQHTGVLKIVTLMVAVWVLAFLVNGPMILVSESWKDEGSECEPGFFSEWYILAITSFLEFVIPVILVAYFNMNIYWSLWKRDHLSRCQSHPGLTAVSSNICGHSFRGRLSSRRSLSASTEVPASFHSERQRRKSSLMFSSRTKMNSNTIASKMGSFSQSDSVALHQREHVELLRARRLAKSLAILLGVFAVCWAPYSLFTIVLSFYSSATGPKSVWYRIAFWLQWFNSFVNPLLYPLCHKRFQKAFLKIFCIKKQPLPSQHSRSVSS
UniProt	Q9H3N8
Protein Data Bank	N/A
GPCR-HGmod model	Q9H3N8
3D structure model	This predicted structure model is from GPCR-EXP Q9H3N8.
BioLiP	N/A
Therapeutic Target Database	T26500
ChEMBL	CHEMBL3759
IUPHAR	265
DrugBank	BE0000146

Ligand

Name	Iodoproxyfan
Molecular formula	C13H15IN2O
IUPAC name	5-[3-[(4-iodophenyl)methoxy]propyl]-1H-imidazole
Molecular weight	342.18
Hydrogen bond acceptor	2
Hydrogen bond donor	1
XlogP	2.7
Synonyms	3-(1H-Imidazol-4-yl)propyl-(4-iodophenyl)methyl ether D08BSG ZINC5117186 5-{3-[(4-iodophenyl)methoxy]propyl}-1H-imidazole (125I)Iodoproxyfan 1H-Imidazole, 4-(3-((4-iodophenyl)methoxy)propyl)- PDSP2_000542 4-[3-[(4-iodophenyl)methoxy]propyl]-3H-imidazole DTXSID30164942 AC1L31V0 L010934 CHEMBL19010 SCHEMBL3089477 5-[3-[(4-iodophenyl)methoxy]propyl]-1H-imidazole GTPL1253 BDBM22916 PDSP1_000544 152028-96-1 [ Show all ]
Inchi Key	DCQNAFOCXVCDLB-UHFFFAOYSA-N
Inchi ID	InChI=1S/C13H15IN2O/c14-12-5-3-11(4-6-12)9-17-7-1-2-13-8-15-10-16-13/h3-6,8,10H,1-2,7,9H2,(H,15,16)
PubChem CID	132937
ChEMBL	CHEMBL19010
IUPHAR	1253
BindingDB	22916
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	12.59 nM	PMID21044842	ChEMBL
Intrinsic activity	0.7 -	PMID21044842	ChEMBL
Ki	12.59 nM	PMID21044842, PMID22003888	BindingDB,ChEMBL
Ki	13.0 nM	PMID15947036	BindingDB

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