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GLASS

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GPCR

Name	Galanin receptor type 3
Species	Homo sapiens (Human)
Gene	GALR3
Synonym	GAL3-R Galnr3 GALR-3 GALR3 GAL3 receptor
Disease	Cognitive disorders
Length	368
Amino acid sequence	MADAQNISLDSPGSVGAVAVPVVFALIFLLGTVGNGLVLAVLLQPGPSAWQEPGSTTDLFILNLAVADLCFILCCVPFQATIYTLDAWLFGALVCKAVHLLIYLTMYASSFTLAAVSVDRYLAVRHPLRSRALRTPRNARAAVGLVWLLAALFSAPYLSYYGTVRYGALELCVPAWEDARRRALDVATFAAGYLLPVAVVSLAYGRTLRFLWAAVGPAGAAAAEARRRATGRAGRAMLAVAALYALCWGPHHALILCFWYGRFAFSPATYACRLASHCLAYANSCLNPLVYALASRHFRARFRRLWPCGRRRRHRARRALRRVRPASSGPPGCPGDARPSGRLLAGGGQGPEPREGPVHGGEAARGPE
UniProt	O60755
Protein Data Bank	N/A
GPCR-HGmod model	O60755
3D structure model	This predicted structure model is from GPCR-EXP O60755.
BioLiP	N/A
Therapeutic Target Database	T98494
ChEMBL	CHEMBL2731
IUPHAR	245
DrugBank	N/A

Ligand

Name	MLS000094981
Molecular formula	C9H6N6O4
IUPAC name	14-ethyl-10-hydroxy-5-oxido-4,9-dioxa-3,8,10,13,15-pentaza-5-azoniatetracyclo[10.3.0.02,6.07,11]pentadeca-1(15),2,5,7,11,13-hexaene
Molecular weight	262.185
Hydrogen bond acceptor	8
Hydrogen bond donor	1
XlogP	0.9
Synonyms	AKOS001742194 STK679912 8-ethyl-1,2,5-oxadiazolo[3,4-e]1,2,5-oxadiazolo[3,4-g]benzimidazole-3,6-diol BRD-K63190004-001-08-7 REGID_for_CID_3236301 A2943/0123933 HMS1551C15 SR-01000091021-1 BDBM34598 MolPort-002-718-027 TimTec1_006043 8-ethyl-7H-imidazo[4,5-e][1,2,5]oxadiazolo[3,4-g][2,1,3]benzoxadiazole 3,6-dioxide (non-preferred name) CHEMBL1455957 SMR000030532 AC1MMBUD HMS2428N08 ST075438 BRD-K63190004-001-07-9 NCGC00052312-02 ZINC3623226 8-ethyl-9H-imidazo[4,5-e][1,2,5]oxadiazolo[3,4-g][2,1,3]benzoxadiazole-1,4-diium-1,4-diolate cid_3236301 SR-01000091021 [ Show all ]
Inchi Key	DCQSADDNJAFBHP-UHFFFAOYSA-N
Inchi ID	InChI=1S/C9H6N6O4/c1-2-3-10-4-5(11-3)8-7(13-19-14(8)16)9-6(4)12-18-15(9)17/h16H,2H2,1H3
PubChem CID	3236301
ChEMBL	N/A
IUPHAR	N/A
BindingDB	34598
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	2058.0 nM	N/A	BindingDB

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