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GPCR

NameGalanin receptor type 3
SpeciesHomo sapiens (Human)
GeneGALR3
SynonymGAL3-R
Galnr3
GALR-3
GALR3
GAL3 receptor
DiseaseCognitive disorders
Length368
Amino acid sequenceMADAQNISLDSPGSVGAVAVPVVFALIFLLGTVGNGLVLAVLLQPGPSAWQEPGSTTDLFILNLAVADLCFILCCVPFQATIYTLDAWLFGALVCKAVHLLIYLTMYASSFTLAAVSVDRYLAVRHPLRSRALRTPRNARAAVGLVWLLAALFSAPYLSYYGTVRYGALELCVPAWEDARRRALDVATFAAGYLLPVAVVSLAYGRTLRFLWAAVGPAGAAAAEARRRATGRAGRAMLAVAALYALCWGPHHALILCFWYGRFAFSPATYACRLASHCLAYANSCLNPLVYALASRHFRARFRRLWPCGRRRRHRARRALRRVRPASSGPPGCPGDARPSGRLLAGGGQGPEPREGPVHGGEAARGPE
UniProtO60755
Protein Data BankN/A
GPCR-HGmod modelO60755
3D structure modelThis predicted structure model is from GPCR-EXP O60755.
BioLiPN/A
Therapeutic Target DatabaseT98494
ChEMBLCHEMBL2731
IUPHAR245
DrugBankN/A

Ligand

NameMLS000094981
Molecular formulaC9H6N6O4
IUPAC name14-ethyl-10-hydroxy-5-oxido-4,9-dioxa-3,8,10,13,15-pentaza-5-azoniatetracyclo[10.3.0.02,6.07,11]pentadeca-1(15),2,5,7,11,13-hexaene
Molecular weight262.185
Hydrogen bond acceptor8
Hydrogen bond donor1
XlogP0.9
Synonyms8-ethyl-1,2,5-oxadiazolo[3,4-e]1,2,5-oxadiazolo[3,4-g]benzimidazole-3,6-diol
BRD-K63190004-001-08-7
REGID_for_CID_3236301
A2943/0123933
HMS1551C15
[ Show all ]
Inchi KeyDCQSADDNJAFBHP-UHFFFAOYSA-N
Inchi IDInChI=1S/C9H6N6O4/c1-2-3-10-4-5(11-3)8-7(13-19-14(8)16)9-6(4)12-18-15(9)17/h16H,2H2,1H3
PubChem CID3236301
ChEMBLN/A
IUPHARN/A
BindingDB34598
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
IC502058.0 nMN/ABindingDB

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