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Name | 5-hydroxytryptamine receptor 1A |
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Species | Homo sapiens (Human) |
Gene | HTR1A |
Synonym | 5-HT-1A 5-HT1A serotonin receptor 1A 5-HT1A receptor 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled [ Show all ] |
Disease | Urinary incontinence Generalized anxiety disorder Generalized anxiety disorder; Social phobia Hypertension Hypoactive sexual desire disorder [ Show all ] |
Length | 422 |
Amino acid sequence | MDVLSPGQGNNTTSPPAPFETGGNTTGISDVTVSYQVITSLLLGTLIFCAVLGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCCTSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGWRTPEDRSDPDACTISKDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVKKVEKTGADTRHGASPAPQPKKSVNGESGSRNWRLGVESKAGGALCANGAVRQGDDGAALEVIEVHRVGNSKEHLPLPSEAGPTPCAPASFERKNERNAEAKRKMALARERKTVKTLGIIMGTFILCWLPFFIVALVLPFCESSCHMPTLLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKFCRQ |
UniProt | P08908 |
Protein Data Bank | N/A |
GPCR-HGmod model | P08908 |
3D structure model | This predicted structure model is from GPCR-EXP P08908. |
BioLiP | N/A |
Therapeutic Target Database | T78709 |
ChEMBL | CHEMBL214 |
IUPHAR | 1 |
DrugBank | BE0000291 |
Name | clozapine |
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Molecular formula | C18H19ClN4 |
IUPAC name | 3-chloro-6-(4-methylpiperazin-1-yl)-11H-benzo[b][1,4]benzodiazepine |
Molecular weight | 326.828 |
Hydrogen bond acceptor | 3 |
Hydrogen bond donor | 1 |
XlogP | 3.1 |
Synonyms | Clozapina [INN-Spanish] 3-chloro-6-(4-methylpiperazin-1-yl)-11H-benzo[b][1,4]benzodiazepine Clozapine [USAN:INN:BAN] 6-chloro-10-(4-methylpiperazin-1-yl)-2,9-diazatricyclo[9.4.0.0(3),]pentadeca-1,3,5,7,10,12,14-heptaene Clozapine, United States Pharmacopeia (USP) Reference Standard [ Show all ] |
Inchi Key | QZUDBNBUXVUHMW-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C18H19ClN4/c1-22-8-10-23(11-9-22)18-14-4-2-3-5-15(14)20-16-7-6-13(19)12-17(16)21-18/h2-7,12,20H,8-11H2,1H3 |
PubChem CID | 135398737 |
ChEMBL | CHEMBL42 |
IUPHAR | 38 |
BindingDB | 50001884 |
DrugBank | DB00363 |
Structure | |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
N/A | N/A | DrugBank | |
IC50 | 150.0 nM | PMID9622542 | BindingDB,ChEMBL |
Ki | 6.38 nM | Med Chem Res, (2013) 22:2:520 | ChEMBL |
Ki | 100.0 nM | PMID17880057 | ChEMBL |
Ki | 101.0 nM | PMID22268448 | BindingDB,ChEMBL |
Ki | 125.893 - 158.489 nM | PMID9760039, PMID8935801, PMID9732398 | IUPHAR |
Ki | 140.0 nM | PMID18595716, PMID24559051 | BindingDB,ChEMBL |
Ki | 143.0 nM | PMID23787101, PMID22926225 | BindingDB,ChEMBL |
Ki | 160.0 nM | PMID25343529 | BindingDB,ChEMBL |
Ki | 270.0 nM | PMID11527728 | BindingDB,ChEMBL |
Ki | 416.87 nM | PMID15261283 | ChEMBL |
Ki | 710.0 nM | PMID11170639 | BindingDB,ChEMBL |
Ki | 1000.0 nM | MedChemComm, (2012) 3:5:580 | ChEMBL |
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