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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	5-hydroxytryptamine receptor 5A
Species	Mus musculus (Mouse)
Gene	Htr5a
Synonym	MR22 Htr5 5HT5- 5-hydroxytryptamine (serotonin) receptor 5A, G protein-coupled 5-HT5alpha 5-HT5A receptor 5-HT5A 5-HT-5A 5-HT-5 Serotonin receptor 5A [ Show all ]
Disease	N/A for non-human GPCRs
Length	357
Amino acid sequence	MDLPVNLTSFSLSTPSSLEPNRSLDTEVLRPSRPFLSAFRVLVLTLLGFLAAATFTWNLLVLATILKVRTFHRVPHNLVASMAISDVLVAVLVMPLSLVHELSGRRWQLGRRLCQLWIACDVLCCTASIWNVTAIALDRYWSITRHLEYTLRTRKRVSNVMILLTWALSTVISLAPLLFGWGETYSEPSEECQVSREPSYTVFSTVGAFYLPLCVVLFVYWKIYRAAKFRMGSRKTNSVSPVPEAVEVKNATQHPQMVFTVRHATVTFQTEGDTWREQKEQRAALMVGILIGVFVLCWFPFFVTELISPLCSWDVPAIWKSIFLWLGYSNSFFNPLIYTAFNRSYSSAFKVFFSKQQ
UniProt	P30966
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3597
IUPHAR	10
DrugBank	N/A

Ligand

Name	clozapine
Molecular formula	C18H19ClN4
IUPAC name	3-chloro-6-(4-methylpiperazin-1-yl)-11H-benzo[b][1,4]benzodiazepine
Molecular weight	326.828
Hydrogen bond acceptor	3
Hydrogen bond donor	1
XlogP	3.1
Synonyms	8-chloro-11-(4-methyl-piperazin-1-yl)-10H-dibenzo[b,e][1,4]diazepine LEX-123 D00283 Tox21_500276 8-Chloro-11-(4-methylpiperazino)-5H-dibenzo[b,e][1,4]diazepine MLS001077282 DSSTox_RID_76759 ZINC19796155 AC1Q3OPZ NCGC00015254-05 Froidir (TN) Azaleptin NCGC00015254-13 HF1854 Bio1_000925 NCGC00022902-04 HMS2096E21 C-36335 NCGC00022902-12 HMS3713E21 CHEBI:92657 Pharmakon1600-01500685 SAM002589962 3-chloro-6-(4-methylpiperazin-1-yl)-5H-benzo[b][1,4]benzodiazepine KBio2_005446 Clozapine [USAN:USP:INN:BAN] SPBio_002340 6-chloro-10-(4-methylpiperazin-1-yl)-2,9-diazatricyclo[9.4.0.03,8]pentadeca-1(11),3,5,7,9,12,14-heptaene KBioSS_000599 Clozapinum SR-01000000096-4 Clozaril (TN) SW220247-1 8-Chloro-11-(4-methyl-piperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepine( Clozepine ) LS-60881 DB00363 W-105432 AB00052158_15 NC00667 EN300-52510 AKOS026749900 NCGC00015254-08 GP7633 BCP25196 NCGC00015254-16 HMS1791P12 Bio2_000790 NCGC00022902-07 HMS3260H14 CAS-5786-21-0 NCGC00260961-01 HY-14539 Clopine (TN) Prestwick_693 KBio1_000343 Clozapine 1.0 mg/ml in Acetonitrile SC-26976 KBio3_000620 Clozapine, British Pharmacopoeia (BP) Reference Standard Spectrum3_001828 8-Chloro-11-(4-methyl)-1-piperazinyl)-5H-dibenzo[b,e][1,4]diazepine L000195 CTK6I2968 Tox21_110113 8-chloro-11-(4-methylpiperazin-1-yl)-10H-dibenzo[b,e][1,4]diazepine MFCD00153785 DSSTox_CID_2855 Z1245633277 AB1009321 NCGC00015254-03 Fazaclo (TN) AOB5635 NCGC00015254-11 HF 1854 BG0154 NCGC00015254-20 HMS2089L13 BRN 0764984 NCGC00022902-10 HMS3402P12 CCRIS 9171 NSC757429 J60AR2IKIC Clozapina s2459 3-chloro-6-(4-methyl-piperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepine KBio2_002878 Clozapine solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material SMR000058365 5H-Dibenzo[b,e][1,4]diazepine, 8-chloro-11-(4-methyl-1-piperazinyl)- KBioGR_001336 Clozapine, solid SR-01000000096 8-Chloro-11-(4-methyl-1-piperazinyl)-5H-dibenzo[b,e][1,4]-diazepine Leponex (TN) 8-Chloro-11-(4-methyl-piperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepine Lopac-C-6305 D0Z1RV UNII-J60AR2IKIC AB00052158-13 MolPort-001-728-041 DTXSID5022855 ZINC3872123 AC1Q3ZWP NCGC00015254-06 FT-0082373 Azaleptine NCGC00015254-14 HMS1361P12 Bio1_001414 NCGC00022902-05 HMS2235E19 C06924 NCGC00022902-13 HMS501B05 Prestwick0_000350 Clozapine (Clozaril) SBI-0050264.P004 3-Hydroxy-2-phenyl-propionic acid 8-methyl-8-aza-bicyclo[3.2.1]oct-3-yl ester KBio2_005735 clozapine(tautomer) SPECTRUM1500685 6-chloro-10-(4-methylpiperazin-1-yl)-2,9-diazatricyclo[9.4.0.0^{3,8}]pentadeca-1,3(8),4,6,10,12,14-heptaene Klozapol (TN) Clozapinum [INN-Latin] SR-01000000096-5 CPD000058365 TC-063560 8-Chloro-11-(4-methyl-piperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepine(Ciozapine) LX 100-129 Denzapine (TN) W-2845 AB00052158_16 NCGC00015254-01 EU-0100276 AN-16004 NCGC00015254-09 GTPL38 BDBM22869 NCGC00015254-17 HMS1921C16 BRD-K37289225-001-09-1 NCGC00022902-08 HMS3266A10 CC0176 NINDS_000343 I06-0047 Clorazil QZUDBNBUXVUHMW-UHFFFAOYSA-N (E)-8-chloro-11-(4-methylpiperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepine KBio2_000310 Clozapine for peak identification, European Pharmacopoeia (EP) Reference Standard SCHEMBL33323 5786-21-0 KBio3_002979 Clozapine, drug standard, 1.0 mg/mL in methanol Spectrum4_000898 8-Chloro-11-(4-methyl-1-piperazinyl)-5H-dibenzo (b,e)(1,4)diazepine L013417 8-Chloro-11-(4-methyl-1-piperazinyl)-5H-dibenzo[b,e][1,4]diazepine Lepotex D-107 Tox21_110113_1 8-chloro-11-(4-methylpiperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepine MLS000028472 DSSTox_GSID_22855 Zaponex (TN) AC1L1EJE NCGC00015254-04 Fazaclo ODT Asaleptin NCGC00015254-12 HF-1854 Bio1_000436 NCGC00022902-02 HMS2092I16 C 6305 NCGC00022902-11 HMS3657E15 CHEBI:3766 Opera_ID_482 Clozapina [INN-Spanish] SAM002548976 3-chloro-6-(4-methylpiperazin-1-yl)-11H-benzo[b][1,4]benzodiazepine KBio2_003167 Clozapine [USAN:INN:BAN] SPBio_000798 6-chloro-10-(4-methylpiperazin-1-yl)-2,9-diazatricyclo[9.4.0.0(3),]pentadeca-1,3,5,7,10,12,14-heptaene KBioSS_000310 Clozapine, United States Pharmacopeia (USP) Reference Standard SR-01000000096-2 8-Chloro-11-(4-methyl-piperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepine (Clozapine) LP00276 Versacloz AB00052158-14 MolPort-006-167-528 EINECS 227-313-7 AKOS005064444 NCGC00015254-07 FT-0600382 BC204168 NCGC00015254-15 HMS1569E21 Bio2_000310 NCGC00022902-06 HMS3259J17 C18H19ClN4 NCGC00188978-01 HSDB 6478 CHEMBL42 Prestwick1_000350 Clozapine (JAN/USP/INN) SC-12183 KBio3_000619 CLOZAPINE, 8-CHLORO-11-(4-METHYL-PIPERAZIN-1-YL)-5H-DIBENZO[B,E][1,4]DIAZEPINE Spectrum2_000919 786C210 KS-1166 CLOZARIL SR-01000000096-8 CS-0644 Tocris-0444 8-Chloro-11-(4-methyl-piperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepine(Clopazine) MCULE-3665900006 DivK1c_000343 W-801 AB0013069 NCGC00015254-02 Fazaclo ANW-42470 NCGC00015254-10 H482 BDBM50001884 NCGC00015254-18 HMS1989P12 BRD-K37289225-001-23-2 NCGC00022902-09 HMS3371H05 CCG-39881 NSC-757429 Iprox Clozapin REGID_for_CID_2818 1333667-72-3 KBio2_000599 Clozapine Resolution Mixture, United States Pharmacopeia (USP) Reference Standard SCHEMBL8397 5H-Dibenzo(b,e)(1,4)diazepine, 8-chloro-11-(4-methyl-1-piperazinyl)- KBioGR_000310 Clozapine, European Pharmacopoeia (EP) Reference Standard Spectrum_000139 8-Chloro-11-(4-methyl-1-piperazinyl)-5H-dibenzo(b,e)(1,4)diazepine Leponex [ Show all ]
Inchi Key	QZUDBNBUXVUHMW-UHFFFAOYSA-N
Inchi ID	InChI=1S/C18H19ClN4/c1-22-8-10-23(11-9-22)18-14-4-2-3-5-15(14)20-16-7-6-13(19)12-17(16)21-18/h2-7,12,20H,8-11H2,1H3
PubChem CID	135398737
ChEMBL	CHEMBL42
IUPHAR	38
BindingDB	50001884
DrugBank	DB00363
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	5011.87 nM	PMID11343685	IUPHAR

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