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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	5-hydroxytryptamine receptor 1A
Species	Mus musculus (Mouse)
Gene	Htr1a
Synonym	5-HT-1A Gpcr18 ADRBRL1 ADRB2RL1 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled 5-HT1A receptor 5-HT1A Serotonin receptor 1A [ Show all ]
Disease	N/A for non-human GPCRs
Length	421
Amino acid sequence	MDMFSLGQGNNTTTSLEPFGTGGNDTGLSNVTFSYQVITSLLLGTLIFCAVLGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCCTSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGWRTPEDRSNPNECTISKDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVKKVEKKGAGTSFGTSSAPPPKKSLNGQPGSGDCRRSAENRAVGTPCANGAVRQGEDDATLEVIEVHRVGNSKGHLPLPSESGATSYVPACLERKNERTAEAKRKMALARERKTVKTLGIIMGTFILCWLPFFIVALVLPFCESSCHMPELLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKFCR
UniProt	Q64264
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3737
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	clozapine
Molecular formula	C18H19ClN4
IUPAC name	3-chloro-6-(4-methylpiperazin-1-yl)-11H-benzo[b][1,4]benzodiazepine
Molecular weight	326.828
Hydrogen bond acceptor	3
Hydrogen bond donor	1
XlogP	3.1
Synonyms	NCGC00015254-01 Fazaclo ANW-42470 NCGC00015254-09 H482 BDBM50001884 NCGC00015254-17 HMS1989P12 BRD-K37289225-001-23-2 NCGC00022902-08 HMS3371H05 CCG-39881 NINDS_000343 Iprox Clozapin QZUDBNBUXVUHMW-UHFFFAOYSA-N 1333667-72-3 KBio2_000310 Clozapine Resolution Mixture, United States Pharmacopeia (USP) Reference Standard SCHEMBL33323 5H-Dibenzo(b,e)(1,4)diazepine, 8-chloro-11-(4-methyl-1-piperazinyl)- KBio3_002979 Clozapine, European Pharmacopoeia (EP) Reference Standard Spectrum4_000898 8-Chloro-11-(4-methyl-1-piperazinyl)-5H-dibenzo(b,e)(1,4)diazepine L013417 CS-0644 TC-063560 8-Chloro-11-(4-methyl-piperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepine(Clopazine) LX 100-129 DivK1c_000343 W-2845 AB0013069 NCGC00015254-04 Froidir (TN) Azaleptin NCGC00015254-12 HF1854 Bio1_000925 NCGC00022902-02 HMS2096E21 C-36335 NCGC00022902-11 HMS3713E21 CHEBI:92657 Opera_ID_482 SAM002548976 3-chloro-6-(4-methylpiperazin-1-yl)-5H-benzo[b][1,4]benzodiazepine KBio2_003167 Clozapine [USAN:USP:INN:BAN] SPBio_000798 6-chloro-10-(4-methylpiperazin-1-yl)-2,9-diazatricyclo[9.4.0.03,8]pentadeca-1(11),3,5,7,9,12,14-heptaene KBioSS_000310 Clozapinum SR-01000000096-2 8-chloro-11-(4-methyl-piperazin-1-yl)-10H-dibenzo[b,e][1,4]diazepine Lepotex D00283 Tox21_110113_1 8-Chloro-11-(4-methylpiperazino)-5H-dibenzo[b,e][1,4]diazepine MLS000028472 DSSTox_RID_76759 Zaponex (TN) AC1Q3OPZ AKOS026749900 NCGC00015254-07 GP7633 BCP25196 NCGC00015254-15 HMS1791P12 Bio2_000790 NCGC00022902-06 HMS3260H14 CAS-5786-21-0 NCGC00188978-01 HY-14539 Clopine (TN) Prestwick1_000350 Clozapine 1.0 mg/ml in Acetonitrile SC-12183 KBio3_000619 Clozapine, British Pharmacopoeia (BP) Reference Standard Spectrum2_000919 8-Chloro-11-(4-methyl)-1-piperazinyl)-5H-dibenzo[b,e][1,4]diazepine KS-1166 Clozaril (TN) SR-01000000096-8 8-Chloro-11-(4-methyl-piperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepine( Clozepine ) LP00276 DB00363 Versacloz AB00052158_15 MolPort-006-167-528 EN300-52510 NCGC00015254-02 Fazaclo (TN) AOB5635 NCGC00015254-10 HF 1854 BG0154 NCGC00015254-18 HMS2089L13 BRN 0764984 NCGC00022902-09 HMS3402P12 CCRIS 9171 NSC-757429 J60AR2IKIC Clozapina REGID_for_CID_2818 3-chloro-6-(4-methyl-piperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepine KBio2_000599 Clozapine solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material SCHEMBL8397 5H-Dibenzo[b,e][1,4]diazepine, 8-chloro-11-(4-methyl-1-piperazinyl)- KBioGR_000310 Clozapine, solid Spectrum_000139 8-Chloro-11-(4-methyl-1-piperazinyl)-5H-dibenzo[b,e][1,4]-diazepine Leponex CTK6I2968 Tocris-0444 8-chloro-11-(4-methylpiperazin-1-yl)-10H-dibenzo[b,e][1,4]diazepine MCULE-3665900006 DSSTox_CID_2855 W-801 AB1009321 ZINC19796155 AC1Q3ZWP NCGC00015254-05 FT-0082373 Azaleptine NCGC00015254-13 HMS1361P12 Bio1_001414 NCGC00022902-04 HMS2235E19 C06924 NCGC00022902-12 HMS501B05 Pharmakon1600-01500685 Clozapine (Clozaril) SAM002589962 3-Hydroxy-2-phenyl-propionic acid 8-methyl-8-aza-bicyclo[3.2.1]oct-3-yl ester KBio2_005446 clozapine(tautomer) SPBio_002340 6-chloro-10-(4-methylpiperazin-1-yl)-2,9-diazatricyclo[9.4.0.0^{3,8}]pentadeca-1,3(8),4,6,10,12,14-heptaene KBioSS_000599 Clozapinum [INN-Latin] SR-01000000096-4 8-Chloro-11-(4-methyl-piperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepine LEX-123 D0Z1RV Tox21_500276 AB00052158-13 MLS001077282 DTXSID5022855 AN-16004 NCGC00015254-08 GTPL38 BDBM22869 NCGC00015254-16 HMS1921C16 BRD-K37289225-001-09-1 NCGC00022902-07 HMS3266A10 CC0176 NCGC00260961-01 I06-0047 Clorazil Prestwick_693 (E)-8-chloro-11-(4-methylpiperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepine KBio1_000343 Clozapine for peak identification, European Pharmacopoeia (EP) Reference Standard SC-26976 5786-21-0 KBio3_000620 Clozapine, drug standard, 1.0 mg/mL in methanol Spectrum3_001828 8-Chloro-11-(4-methyl-1-piperazinyl)-5H-dibenzo (b,e)(1,4)diazepine L000195 CPD000058365 SW220247-1 8-Chloro-11-(4-methyl-piperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepine(Ciozapine) LS-60881 Denzapine (TN) W-105432 AB00052158_16 NC00667 EU-0100276 NCGC00015254-03 Fazaclo ODT Asaleptin NCGC00015254-11 HF-1854 Bio1_000436 NCGC00015254-20 HMS2092I16 C 6305 NCGC00022902-10 HMS3657E15 CHEBI:3766 NSC757429 Clozapina [INN-Spanish] s2459 3-chloro-6-(4-methylpiperazin-1-yl)-11H-benzo[b][1,4]benzodiazepine KBio2_002878 Clozapine [USAN:INN:BAN] SMR000058365 6-chloro-10-(4-methylpiperazin-1-yl)-2,9-diazatricyclo[9.4.0.0(3),]pentadeca-1,3,5,7,10,12,14-heptaene KBioGR_001336 Clozapine, United States Pharmacopeia (USP) Reference Standard SR-01000000096 8-Chloro-11-(4-methyl-1-piperazinyl)-5H-dibenzo[b,e][1,4]diazepine Leponex (TN) D-107 Tox21_110113 8-chloro-11-(4-methylpiperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepine MFCD00153785 DSSTox_GSID_22855 Z1245633277 AC1L1EJE ZINC3872123 AKOS005064444 NCGC00015254-06 FT-0600382 BC204168 NCGC00015254-14 HMS1569E21 Bio2_000310 NCGC00022902-05 HMS3259J17 C18H19ClN4 NCGC00022902-13 HSDB 6478 CHEMBL42 Prestwick0_000350 Clozapine (JAN/USP/INN) SBI-0050264.P004 KBio2_005735 CLOZAPINE, 8-CHLORO-11-(4-METHYL-PIPERAZIN-1-YL)-5H-DIBENZO[B,E][1,4]DIAZEPINE SPECTRUM1500685 786C210 Klozapol (TN) CLOZARIL SR-01000000096-5 8-Chloro-11-(4-methyl-piperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepine (Clozapine) Lopac-C-6305 UNII-J60AR2IKIC AB00052158-14 MolPort-001-728-041 EINECS 227-313-7 [ Show all ]
Inchi Key	QZUDBNBUXVUHMW-UHFFFAOYSA-N
Inchi ID	InChI=1S/C18H19ClN4/c1-22-8-10-23(11-9-22)18-14-4-2-3-5-15(14)20-16-7-6-13(19)12-17(16)21-18/h2-7,12,20H,8-11H2,1H3
PubChem CID	135398737
ChEMBL	CHEMBL42
IUPHAR	38
BindingDB	50001884
DrugBank	DB00363
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	2000.0 nM	PMID8941382	BindingDB,ChEMBL

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