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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	D(1) dopamine receptor
Species	Carassius auratus (Goldfish)
Gene
Synonym	Dopamine D1 receptor
Disease	N/A for non-human GPCRs
Length	363
Amino acid sequence	MAVLDLNLTTVIDSGFMESDRSVRVLTGCFLSVLILSTLLGNTLVCAAVTKFRHLRSKVTNFFVISLAVSDLLVAVLVMPWKAVTEVAGFWPFGAFCDIWVAFDIMCSTASILNLCVISVDRYWAISSPFRYERKMTPRVAFVMISGAWTLSVLISFIPVQLKWHKAQPIGFLEVNASRRDLPTDNCDSSLNRTYAISSSLISFYIPVAIMIVTYTQIYRIAQKQIRRISALERAAESAQIRHDSMGSGSNMDLESSFKLSFKRETKVLKTLSVIMGVFVCCWLPFFILNCMVPFCKRTSNGLPCISPTTFDVFVWFGWANSSLNPIIYAFNADFRRAFAILLGCQRLCPGSISMETPSLNKN
UniProt	P35406
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL2368
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	CHEMBL544099
Molecular formula	C18H27NO2
IUPAC name	(1R,3S)-3-cyclohexyl-6-methyl-1-(methylaminomethyl)-3,4-dihydro-1H-isochromen-5-ol
Molecular weight	289.419
Hydrogen bond acceptor	3
Hydrogen bond donor	2
XlogP	3.7
Synonyms	3-Cyclohexyl-6-methyl-1-methylaminomethyl-isochroman-5-ol; hydrobromide CHEMBL1192799 (1R)-1alpha-(Methylaminomethyl)-3,4-dihydro-3alpha-cyclohexyl-6-methyl-1H-2-benzopyran-5-ol BDBM50008831 SCHEMBL9802511
Inchi Key	TWJRNAUVADBAOE-IRXDYDNUSA-N
Inchi ID	InChI=1S/C18H27NO2/c1-12-8-9-14-15(18(12)20)10-16(21-17(14)11-19-2)13-6-4-3-5-7-13/h8-9,13,16-17,19-20H,3-7,10-11H2,1-2H3/t16-,17-/m0/s1
PubChem CID	15711855
ChEMBL	N/A
IUPHAR	N/A
BindingDB	50008831
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	121.0 nM	PMID1833546	BindingDB

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