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GLASS

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GPCR

Name	Corticotropin-releasing factor receptor 2
Species	Mus musculus (Mouse)
Gene	Crhr2
Synonym	CRFR-2 CRFR2 CRFR2alpha CRFR2beta CRH-R-2 CRF2 receptor CRF-RB CRF-R2 CRF-R-2 CRF 2 receptor Corticotropin-releasing hormone receptor 2 CRH-R2 [ Show all ]
Disease	N/A for non-human GPCRs
Length	411
Amino acid sequence	MDAALLLSLLEANCSLALAEELLLDGWGVPPDPEGPYTYCNTTLDQIGTCWPQSAPGALVERPCPEYFNGIKYNTTRNAYRECLENGTWASRVNYSHCEPILDDKQRKYDLHYRIALIVNYLGHCVSVVALVAAFLLFLVLRSIRCLRNVIHWNLITTFILRNIAWFLLQLIDHEVHEGNEVWCRCITTIFNYFVVTNFFWMFVEGCYLHTAIVMTYSTEHLRKWLFLFIGWCIPCPIIIAWAVGKLYYENEQCWFGKEAGDLVDYIYQGPVMLVLLINFVFLFNIVRILMTKLRASTTSETIQYRKAVKATLVLLPLLGITYMLFFVNPGEDDLSQIVFIYFNSFLQSFQGFFVSVFYCFFNGEVRAALRKRWHRWQDHHALRVPVARAMSIPTSPTRISFHSIKQTAAV
UniProt	Q60748
Protein Data Bank	2jnd
GPCR-HGmod model	N/A
3D structure model	This structure is from PDB ID 2jnd.
BioLiP	BL0101313
Therapeutic Target Database	N/A
ChEMBL	CHEMBL2253
IUPHAR	213
DrugBank	N/A

Ligand

Name	CHEMBL352154
Molecular formula	C24H24N6O2
IUPAC name	(4R,9R)-N-(2-aminoethyl)-24-hydroxy-3,10,14,16-tetrazahexacyclo[11.11.1.02,11.04,9.017,25.018,23]pentacosa-1(24),2,11,13,15,17(25),18,20,22-nonaene-12-carboxamide
Molecular weight	428.496
Hydrogen bond acceptor	7
Hydrogen bond donor	4
XlogP	1.7
Synonyms	8N-(2-aminoethyl)-15-oxo-9a,10,11,12,13,13a,14,15-octahydro-9H-benzo[7,8]quinazolino[5,4-ab]phenazine-8-carboxamide BDBM50075917 N-(2-Aminoethyl)-5,6-[imino(cyclohexane-1beta,2alpha-diyl)imino]-7-oxo-7H-benzo[e]perimidine-4-carboxamide
Inchi Key	WDYQSAPKHJAPBL-HUUCEWRRSA-N
Inchi ID	InChI=1S/C24H24N6O2/c25-9-10-26-24(32)18-20-16-17(21-22(18)30-15-8-4-3-7-14(15)29-21)23(31)13-6-2-1-5-12(13)19(16)27-11-28-20/h1-2,5-6,11,14-15,30-31H,3-4,7-10,25H2,(H,26,32)/t14-,15-/m1/s1
PubChem CID	135444727
ChEMBL	CHEMBL352154
IUPHAR	N/A
BindingDB	50075917
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	45.0 nM	PMID10201844	BindingDB,ChEMBL

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