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Name | Galanin receptor type 2 |
---|---|
Species | Homo sapiens (Human) |
Gene | GALR2 |
Synonym | GAL2 receptor GAL2-R GALNR2 GALR-2 |
Disease | N/A |
Length | 387 |
Amino acid sequence | MNVSGCPGAGNASQAGGGGGWHPEAVIVPLLFALIFLVGTVGNTLVLAVLLRGGQAVSTTNLFILNLGVADLCFILCCVPFQATIYTLDGWVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFSGPYLSYYRQSQLANLTVCHPAWSAPRRRAMDICTFVFSYLLPVLVLGLTYARTLRYLWRAVDPVAAGSGARRAKRKVTRMILIVAALFCLCWMPHHALILCVWFGQFPLTRATYALRILSHLVSYANSCVNPIVYALVSKHFRKGFRTICAGLLGRAPGRASGRVCAAARGTHSGSVLERESSDLLHMSEAAGALRPCPGASQPCILEPCPGPSWQGPKAGDSILTVDVA |
UniProt | O43603 |
Protein Data Bank | N/A |
GPCR-HGmod model | O43603 |
3D structure model | This predicted structure model is from GPCR-EXP O43603. |
BioLiP | N/A |
Therapeutic Target Database | N/A |
ChEMBL | CHEMBL3176 |
IUPHAR | 244 |
DrugBank | N/A |
Name | CHEMBL1922014 |
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Molecular formula | C22H23ClFN5O |
IUPAC name | 4-N-(3-chloro-4-fluorophenyl)-2-N-(4-methoxyphenyl)-6-piperidin-1-ylpyrimidine-2,4-diamine |
Molecular weight | 427.908 |
Hydrogen bond acceptor | 7 |
Hydrogen bond donor | 2 |
XlogP | 6.0 |
Synonyms | BDBM50358684 |
Inchi Key | DEKAAPINAQALIV-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C22H23ClFN5O/c1-30-17-8-5-15(6-9-17)26-22-27-20(25-16-7-10-19(24)18(23)13-16)14-21(28-22)29-11-3-2-4-12-29/h5-10,13-14H,2-4,11-12H2,1H3,(H2,25,26,27,28) |
PubChem CID | 57394241 |
ChEMBL | CHEMBL1922014 |
IUPHAR | N/A |
BindingDB | 50358684 |
DrugBank | N/A |
Structure | ![]() |
Lipinski's druglikeness | This ligand has a partition coefficient log P greater than 5. |
Parameter | Value | Reference | Database source |
---|---|---|---|
IC50 | 4180.0 nM | PMID22018787 | BindingDB,ChEMBL |
Inhibition | <50.0 % | PMID22018787 | ChEMBL |
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