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GPCR

Name5-hydroxytryptamine receptor 4
SpeciesCavia porcellus (Guinea pig)
GeneHTR4
Synonym5-HT-4
5-HT4
Serotonin receptor 4
DiseaseN/A for non-human GPCRs
Length388
Amino acid sequenceMDKLDANVSSKEGFGSVEKVVLLTFLSAVILMAILGNLLVMVAVCRDRQLRKIKTNYFIVSLAFADLLVSVLVMPFGAIELVQDIWVYGEMFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNKMTPLRIALMLGGCWVIPMFISFLPIMQGWNNIGIVDLIEKRKFNQNSNSTYCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHARQIQVLQRAGAPAEGRPQPADQHSTHRMRTETKAAKTLCIIMGCFCLCWAPFFVTNIVDPFIDYTVPGQLWTAFLWLGYINSGLNPFLYAFLNKSFRRAFLIILCCDDERYRRPSILGQTVPCSTTTINGSTHVLRDTVECGGQWESQCHPAASSPLVAAQPIDT
UniProtO70528
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL5017
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL156348
Molecular formulaC17H24ClN3O4
IUPAC name2-(4-acetamidopiperidin-1-yl)ethyl 4-amino-5-chloro-2-methoxybenzoate
Molecular weight369.846
Hydrogen bond acceptor6
Hydrogen bond donor2
XlogP1.6
SynonymsBDBM50056416
SCHEMBL9117930
4-Amino-5-chloro-2-methoxy-benzoic acid 2-(4-acetylamino-piperidin-1-yl)-ethyl ester
Inchi KeyDEKWIDJXEYNIHF-UHFFFAOYSA-N
Inchi IDInChI=1S/C17H24ClN3O4/c1-11(22)20-12-3-5-21(6-4-12)7-8-25-17(23)13-9-14(18)15(19)10-16(13)24-2/h9-10,12H,3-8,19H2,1-2H3,(H,20,22)
PubChem CID10690483
ChEMBLCHEMBL156348
IUPHARN/A
BindingDB50056416
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Activity59.0 %PMID9046352ChEMBL
EC5013.0 nMPMID9046352BindingDB,ChEMBL

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