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GPCR

NamePlatelet-activating factor receptor
SpeciesHomo sapiens (Human)
GenePTAFR
SynonymPAFr
PAF-R
PAF receptor
AGEPC receptor
DiseaseNerve injury
Ocular allergy
Pain
Unspecified
Psoriasis
[ Show all ]
Length342
Amino acid sequenceMEPHDSSHMDSEFRYTLFPIVYSIIFVLGVIANGYVLWVFARLYPCKKFNEIKIFMVNLTMADMLFLITLPLWIVYYQNQGNWILPKFLCNVAGCLFFINTYCSVAFLGVITYNRFQAVTRPIKTAQANTRKRGISLSLVIWVAIVGAASYFLILDSTNTVPDSAGSGNVTRCFEHYEKGSVPVLIIHIFIVFSFFLVFLIILFCNLVIIRTLLMQPVQQQRNAEVKRRALWMVCTVLAVFIICFVPHHVVQLPWTLAELGFQDSKFHQAINDAHQVTLCLLSTNCVLDPVIYCFLTKKFRKHLTEKFYSMRSSRKCSRATTDTVTEVVVPFNQIPGNSLKN
UniProtP25105
Protein Data Bank5zkq, 5zkp
GPCR-HGmod modelP25105
3D structure modelThis structure is from PDB ID 5zkq.
BioLiPBL0417415, BL0417417,BL0417419, BL0417416,BL0417418, BL0417414
Therapeutic Target DatabaseT87023
ChEMBLCHEMBL250
IUPHAR334
DrugBankBE0005561

Ligand

NameCHEMBL52615
Molecular formulaC26H24Cl2N2O
IUPAC name(2E)-5,5-bis(4-chlorophenyl)-N-(4-pyridin-3-ylbutyl)penta-2,4-dienamide
Molecular weight451.391
Hydrogen bond acceptor2
Hydrogen bond donor1
XlogP7.0
Synonyms(E)-5,5-bis(4-chlorophenyl)-N-[4-(3-pyridinyl)butyl]-2,4-pentadienamide
SCHEMBL9520309
BDBM50018387
DFAASFDJHUBGFH-FPYGCLRLSA-N
5,5-Bis-(4-chloro-phenyl)-penta-2,4-dienoic acid (4-pyridin-3-yl-butyl)-amide
[ Show all ]
Inchi KeyDFAASFDJHUBGFH-FPYGCLRLSA-N
Inchi IDInChI=1S/C26H24Cl2N2O/c27-23-13-9-21(10-14-23)25(22-11-15-24(28)16-12-22)7-3-8-26(31)30-18-2-1-5-20-6-4-17-29-19-20/h3-4,6-17,19H,1-2,5,18H2,(H,30,31)/b8-3+
PubChem CID14347341
ChEMBLCHEMBL52615
IUPHARN/A
BindingDB50018387
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has a partition coefficient log P greater than 5.

Experimental Data

ParameterValueReferenceDatabase source
IC5060.0 nMPMID2754709BindingDB,ChEMBL

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