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Name | Endothelin receptor type B |
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Species | Homo sapiens (Human) |
Gene | EDNRB |
Synonym | endothelin B receptor HSCR2 HSCR ETB receptor ET-BR [ Show all ] |
Disease | Arrhythmia Hypertension Pulmonary arterial hypertension Solid tumours Cancer [ Show all ] |
Length | 442 |
Amino acid sequence | MQPPPSLCGRALVALVLACGLSRIWGEERGFPPDRATPLLQTAEIMTPPTKTLWPKGSNASLARSLAPAEVPKGDRTAGSPPRTISPPPCQGPIEIKETFKYINTVVSCLVFVLGIIGNSTLLRIIYKNKCMRNGPNILIASLALGDLLHIVIDIPINVYKLLAEDWPFGAEMCKLVPFIQKASVGITVLSLCALSIDRYRAVASWSRIKGIGVPKWTAVEIVLIWVVSVVLAVPEAIGFDIITMDYKGSYLRICLLHPVQKTAFMQFYKTAKDWWLFSFYFCLPLAITAFFYTLMTCEMLRKKSGMQIALNDHLKQRREVAKTVFCLVLVFALCWLPLHLSRILKLTLYNQNDPNRCELLSFLLVLDYIGINMASLNSCINPIALYLVSKRFKNCFKSCLCCWCQSFEEKQSLEEKQSCLKFKANDHGYDNFRSSNKYSSS |
UniProt | P24530 |
Protein Data Bank | 6igl, 6igk, 5xpr, 5x93 |
GPCR-HGmod model | P24530 |
3D structure model | This structure is from PDB ID 6igl. |
BioLiP | BL0388813, BL0433639, BL0433638, BL0388896, BL0388814 |
Therapeutic Target Database | T92828 |
ChEMBL | CHEMBL1785 |
IUPHAR | 220 |
DrugBank | BE0000043 |
Name | CHEMBL70924 |
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Molecular formula | C30H34N6O6S |
IUPAC name | 1-[2-[6-[(4-tert-butylphenyl)sulfonylamino]-5-(2-methoxyphenoxy)-2-methylpyrimidin-4-yl]oxyethyl]-3-pyridin-2-ylurea |
Molecular weight | 606.698 |
Hydrogen bond acceptor | 10 |
Hydrogen bond donor | 3 |
XlogP | 4.9 |
Synonyms | BDBM50290058 SCHEMBL8322960 4-tert-Butyl-N-{5-(2-methoxy-phenoxy)-2-methyl-6-[2-(3-pyridin-2-yl-ureido)-ethoxy]-pyrimidin-4-yl}-benzenesulfonamide |
Inchi Key | AHRRXSCSEHTVQL-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C30H34N6O6S/c1-20-33-27(36-43(38,39)22-15-13-21(14-16-22)30(2,3)4)26(42-24-11-7-6-10-23(24)40-5)28(34-20)41-19-18-32-29(37)35-25-12-8-9-17-31-25/h6-17H,18-19H2,1-5H3,(H,33,34,36)(H2,31,32,35,37) |
PubChem CID | 19432672 |
ChEMBL | CHEMBL70924 |
IUPHAR | N/A |
BindingDB | 50290058 |
DrugBank | N/A |
Structure | ![]() |
Lipinski's druglikeness | This ligand is heavier than 500 daltons. |
Parameter | Value | Reference | Database source |
---|---|---|---|
IC50 | 1240.0 nM | , Bioorg. Med. Chem. Lett., (1997) 7:17:2223 | BindingDB,ChEMBL |
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