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Name | Platelet-activating factor receptor |
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Species | Homo sapiens (Human) |
Gene | PTAFR |
Synonym | PAFr PAF-R PAF receptor AGEPC receptor |
Disease | Nerve injury Ocular allergy Pain Unspecified Psoriasis [ Show all ] |
Length | 342 |
Amino acid sequence | MEPHDSSHMDSEFRYTLFPIVYSIIFVLGVIANGYVLWVFARLYPCKKFNEIKIFMVNLTMADMLFLITLPLWIVYYQNQGNWILPKFLCNVAGCLFFINTYCSVAFLGVITYNRFQAVTRPIKTAQANTRKRGISLSLVIWVAIVGAASYFLILDSTNTVPDSAGSGNVTRCFEHYEKGSVPVLIIHIFIVFSFFLVFLIILFCNLVIIRTLLMQPVQQQRNAEVKRRALWMVCTVLAVFIICFVPHHVVQLPWTLAELGFQDSKFHQAINDAHQVTLCLLSTNCVLDPVIYCFLTKKFRKHLTEKFYSMRSSRKCSRATTDTVTEVVVPFNQIPGNSLKN |
UniProt | P25105 |
Protein Data Bank | 5zkq, 5zkp |
GPCR-HGmod model | P25105 |
3D structure model | This structure is from PDB ID 5zkq. |
BioLiP | BL0417415, BL0417417,BL0417419, BL0417416,BL0417418, BL0417414 |
Therapeutic Target Database | T87023 |
ChEMBL | CHEMBL250 |
IUPHAR | 334 |
DrugBank | BE0005561 |
Name | CHEMBL53149 |
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Molecular formula | C26H24Cl2N2O |
IUPAC name | (2E)-5,5-bis(3-chlorophenyl)-N-(4-pyridin-3-ylbutyl)penta-2,4-dienamide |
Molecular weight | 451.391 |
Hydrogen bond acceptor | 2 |
Hydrogen bond donor | 1 |
XlogP | 7.0 |
Synonyms | BDBM50018376 DFLJFWPHOWAYHJ-LHHJGKSTSA-N 5,5-Bis-(3-chloro-phenyl)-penta-2,4-dienoic acid (4-pyridin-3-yl-butyl)-amide SCHEMBL10398584 (E)-5,5-bis(3-chlorophenyl)-N-[4-(3-pyridinyl)butyl]-2,4-pentadienamide [ Show all ] |
Inchi Key | DFLJFWPHOWAYHJ-LHHJGKSTSA-N |
Inchi ID | InChI=1S/C26H24Cl2N2O/c27-23-11-3-9-21(17-23)25(22-10-4-12-24(28)18-22)13-5-14-26(31)30-16-2-1-7-20-8-6-15-29-19-20/h3-6,8-15,17-19H,1-2,7,16H2,(H,30,31)/b14-5+ |
PubChem CID | 14347340 |
ChEMBL | CHEMBL53149 |
IUPHAR | N/A |
BindingDB | 50018376 |
DrugBank | N/A |
Structure | ![]() |
Lipinski's druglikeness | This ligand has a partition coefficient log P greater than 5. |
Parameter | Value | Reference | Database source |
---|---|---|---|
IC50 | 25.0 nM | PMID2754709 | BindingDB,ChEMBL |
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