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Name | C5a anaphylatoxin chemotactic receptor 1 |
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Species | Homo sapiens (Human) |
Gene | C5AR1 |
Synonym | complement component 5a receptor 1 complement C5a receptor C5A CD88 C5R1 [ Show all ] |
Disease | Vasculitis Atopic dermatitis Inflammatory disease Rheumatoid arthritis |
Length | 350 |
Amino acid sequence | MDSFNYTTPDYGHYDDKDTLDLNTPVDKTSNTLRVPDILALVIFAVVFLVGVLGNALVVWVTAFEAKRTINAIWFLNLAVADFLSCLALPILFTSIVQHHHWPFGGAACSILPSLILLNMYASILLLATISADRFLLVFKPIWCQNFRGAGLAWIACAVAWGLALLLTIPSFLYRVVREEYFPPKVLCGVDYSHDKRRERAVAIVRLVLGFLWPLLTLTICYTFILLRTWSRRATRSTKTLKVVVAVVASFFIFWLPYQVTGIMMSFLEPSSPTFLLLKKLDSLCVSFAYINCCINPIIYVVAGQGFQGRLRKSLPSLLRNVLTEESVVRESKSFTRSTVDTMAQKTQAV |
UniProt | P21730 |
Protein Data Bank | 6c1r, 6c1q, 5o9h |
GPCR-HGmod model | P21730 |
3D structure model | This structure is from PDB ID 6c1r. |
BioLiP | BL0415511, BL0415514, BL0415513, BL0415512, BL0401194,BL0401195,BL0401196, |
Therapeutic Target Database | T15439 |
ChEMBL | CHEMBL2373 |
IUPHAR | 32 |
DrugBank | N/A |
Name | diamide 7 |
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Molecular formula | C22H22N2O3S |
IUPAC name | N-[2-(2,6-dimethylanilino)-1-(5-methylthiophen-2-yl)-2-oxoethyl]-2-hydroxybenzamide |
Molecular weight | 394.489 |
Hydrogen bond acceptor | 4 |
Hydrogen bond donor | 3 |
XlogP | 4.8 |
Synonyms | CHEMBL1770298 GTPL5830 BDBM50418334 D0G5DH N-[2-(2,6-dimethylanilino)-1-(5-methylthiophen-2-yl)-2-oxoethyl]-2-hydroxybenzamide |
Inchi Key | AHTURLVFIJHCLS-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C22H22N2O3S/c1-13-7-6-8-14(2)19(13)23-22(27)20(18-12-11-15(3)28-18)24-21(26)16-9-4-5-10-17(16)25/h4-12,20,25H,1-3H3,(H,23,27)(H,24,26) |
PubChem CID | 53233899 |
ChEMBL | CHEMBL1770298 |
IUPHAR | 5830 |
BindingDB | 50418334 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
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Inhibition | >25.0 % | PMID21486695 | ChEMBL |
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