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GPCR

NameCysteinyl leukotriene receptor 1
SpeciesCavia porcellus (Guinea pig)
GeneCYSLTR1
SynonymCysLTR1
Cysteinyl leukotriene D4 receptor
LTD4 receptor
DiseaseN/A for non-human GPCRs
Length340
Amino acid sequenceMDETGNPTIPPASNNTCYDSIDDFRNQVYSTLYSMISVVGFFGNGFVLYVLVKTYHEKSAFQVYMINLAVADLLCVCTLPLRVAYYVHKGIWLFGDFLCRLSTYALYVNLYCSIFFMTAMSFFRCVAIVFPVQNISLVTQKKARLVCIAIWMFVILTSSPFLMANTYKDEKNNTKCFEPPQDNQAKNYVLILHYVSLFIGFIIPFITIIVCYTMIIFTLLKSSMKKNLSSRKRAIGMIIVVTAAFLVSFMPYHIQRTIHLHFLHNKTKPCDSILRMQKSVVITLSLAASNCCFDPLLYFFSGGNFRRRLSTIRKYSLSSMTYIPKKKTSLPQKGKDICKE
UniProtQ2NNR5
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL5645
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL18979
Molecular formulaC24H19NO4
IUPAC name3-[[3-(quinolin-2-ylmethoxy)phenoxy]methyl]benzoic acid
Molecular weight385.419
Hydrogen bond acceptor5
Hydrogen bond donor1
XlogP4.7
SynonymsL002770
3-(3-(2-quinolinylmethyloxy)phenoxymethyl)benzoic acid
SCHEMBL7010090
3-[3-(2-Quinolylmethoxy)phenoxymethyl]benzoic acid
AHUWRVUAJPFGPN-UHFFFAOYSA-N
[ Show all ]
Inchi KeyAHUWRVUAJPFGPN-UHFFFAOYSA-N
Inchi IDInChI=1S/C24H19NO4/c26-24(27)19-7-3-5-17(13-19)15-28-21-8-4-9-22(14-21)29-16-20-12-11-18-6-1-2-10-23(18)25-20/h1-14H,15-16H2,(H,26,27)
PubChem CID9952064
ChEMBLCHEMBL18979
IUPHARN/A
BindingDB50013551
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Ki40.0 nMPMID2157010BindingDB,ChEMBL

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