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GPCR

NameGalanin receptor type 3
SpeciesHomo sapiens (Human)
GeneGALR3
SynonymGAL3-R
Galnr3
GALR-3
GALR3
GAL3 receptor
DiseaseCognitive disorders
Length368
Amino acid sequenceMADAQNISLDSPGSVGAVAVPVVFALIFLLGTVGNGLVLAVLLQPGPSAWQEPGSTTDLFILNLAVADLCFILCCVPFQATIYTLDAWLFGALVCKAVHLLIYLTMYASSFTLAAVSVDRYLAVRHPLRSRALRTPRNARAAVGLVWLLAALFSAPYLSYYGTVRYGALELCVPAWEDARRRALDVATFAAGYLLPVAVVSLAYGRTLRFLWAAVGPAGAAAAEARRRATGRAGRAMLAVAALYALCWGPHHALILCFWYGRFAFSPATYACRLASHCLAYANSCLNPLVYALASRHFRARFRRLWPCGRRRRHRARRALRRVRPASSGPPGCPGDARPSGRLLAGGGQGPEPREGPVHGGEAARGPE
UniProtO60755
Protein Data BankN/A
GPCR-HGmod modelO60755
3D structure modelThis predicted structure model is from GPCR-EXP O60755.
BioLiPN/A
Therapeutic Target DatabaseT98494
ChEMBLCHEMBL2731
IUPHAR245
DrugBankN/A

Ligand

NameMLS000730667
Molecular formulaC19H26ClN3O2
IUPAC name2-(1-adamantyl)-4-chloro-5-(oxolan-2-ylmethylamino)pyridazin-3-one
Molecular weight363.886
Hydrogen bond acceptor4
Hydrogen bond donor1
XlogP3.6
SynonymsMolPort-004-882-256
AKOS022034467
SR-01000124935-1
2-(1-adamantyl)-4-chloro-5-(oxolan-2-ylmethylamino)pyridazin-3-one
CHEMBL1523593
[ Show all ]
Inchi KeyAHXHATFSBJZLMF-UHFFFAOYSA-N
Inchi IDInChI=1S/C19H26ClN3O2/c20-17-16(21-10-15-2-1-3-25-15)11-22-23(18(17)24)19-7-12-4-13(8-19)6-14(5-12)9-19/h11-15,21H,1-10H2
PubChem CID16193721
ChEMBLCHEMBL1523593
IUPHARN/A
BindingDB97105
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
IC50<29910.0 nM, PubChem BioAssay data setBindingDB,ChEMBL

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