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Name | Platelet-activating factor receptor |
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Species | Homo sapiens (Human) |
Gene | PTAFR |
Synonym | PAFr PAF-R PAF receptor AGEPC receptor |
Disease | Nerve injury Ocular allergy Pain Unspecified Psoriasis [ Show all ] |
Length | 342 |
Amino acid sequence | MEPHDSSHMDSEFRYTLFPIVYSIIFVLGVIANGYVLWVFARLYPCKKFNEIKIFMVNLTMADMLFLITLPLWIVYYQNQGNWILPKFLCNVAGCLFFINTYCSVAFLGVITYNRFQAVTRPIKTAQANTRKRGISLSLVIWVAIVGAASYFLILDSTNTVPDSAGSGNVTRCFEHYEKGSVPVLIIHIFIVFSFFLVFLIILFCNLVIIRTLLMQPVQQQRNAEVKRRALWMVCTVLAVFIICFVPHHVVQLPWTLAELGFQDSKFHQAINDAHQVTLCLLSTNCVLDPVIYCFLTKKFRKHLTEKFYSMRSSRKCSRATTDTVTEVVVPFNQIPGNSLKN |
UniProt | P25105 |
Protein Data Bank | 5zkq, 5zkp |
GPCR-HGmod model | P25105 |
3D structure model | This structure is from PDB ID 5zkq. |
BioLiP | BL0417415, BL0417417,BL0417419, BL0417416,BL0417418, BL0417414 |
Therapeutic Target Database | T87023 |
ChEMBL | CHEMBL250 |
IUPHAR | 334 |
DrugBank | BE0005561 |
Name | CHEMBL56418 |
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Molecular formula | C23H22N4O3 |
IUPAC name | 3-methoxy-11-oxo-N-(4-pyridin-3-ylbutyl)pyrido[2,1-b]quinazoline-8-carboxamide |
Molecular weight | 402.454 |
Hydrogen bond acceptor | 5 |
Hydrogen bond donor | 1 |
XlogP | 2.1 |
Synonyms | SCHEMBL11009466 3-Methoxy-11-oxo-11H-pyrido[2,1-b]quinazoline-8-carboxylic acid (4-pyridin-3-yl-butyl)-amide BDBM50019678 |
Inchi Key | DGYJMRJVVGLCDV-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C23H22N4O3/c1-30-18-8-9-19-20(13-18)26-21-10-7-17(15-27(21)23(19)29)22(28)25-12-3-2-5-16-6-4-11-24-14-16/h4,6-11,13-15H,2-3,5,12H2,1H3,(H,25,28) |
PubChem CID | 13557494 |
ChEMBL | CHEMBL56418 |
IUPHAR | N/A |
BindingDB | 50019678 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
IC50 | 370.0 nM | PMID3339617 | BindingDB,ChEMBL |
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