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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Neuropeptide Y receptor type 1
Species	Homo sapiens (Human)
Gene	NPY1R
Synonym	neuropeptide Y receptor type 1 NPY-Y1 receptor NPY1-R FC5 Y1 receptor Y1-R [ Show all ]
Disease	Hypertension; Obesity; Heart disease Obesity Eating disorders reduction in food intake obesity anxiety Eating disorders reduction in food intake Eating disorder Cardiovascular disorder Hypertension [ Show all ]
Length	384
Amino acid sequence	MNSTLFSQVENHSVHSNFSEKNAQLLAFENDDCHLPLAMIFTLALAYGAVIILGVSGNLALIIIILKQKEMRNVTNILIVNLSFSDLLVAIMCLPFTFVYTLMDHWVFGEAMCKLNPFVQCVSITVSIFSLVLIAVERHQLIINPRGWRPNNRHAYVGIAVIWVLAVASSLPFLIYQVMTDEPFQNVTLDAYKDKYVCFDQFPSDSHRLSYTTLLLVLQYFGPLCFIFICYFKIYIRLKRRNNMMDKMRDNKYRSSETKRINIMLLSIVVAFAVCWLPLTIFNTVFDWNHQIIATCNHNLLFLLCHLTAMISTCVNPIFYGFLNKNFQRDLQFFFNFCDFRSRDDDYETIAMSTMHTDVSKTSLKQASPVAFKKINNNDDNEKI
UniProt	P25929
Protein Data Bank	5zbh
GPCR-HGmod model	P25929
3D structure model	This structure is from PDB ID 5zbh.
BioLiP	BL0411971
Therapeutic Target Database	T89213
ChEMBL	CHEMBL4777
IUPHAR	305
DrugBank	N/A

Ligand

Name	CHEMBL1076276
Molecular formula	C22H26N4S2
IUPAC name	N-[2-[4-[[(4R)-4-(2-methylpropyl)-4,5-dihydro-1,3-thiazol-2-yl]amino]phenyl]ethyl]-1,3-benzothiazol-2-amine
Molecular weight	410.598
Hydrogen bond acceptor	5
Hydrogen bond donor	2
XlogP	6.2
Synonyms	BDBM50312029 SCHEMBL14000943 (R)-N-(4-(4-isobutyl-4,5-dihydrothiazol-2-ylamino)phenethyl)benzo[d]thiazol-2-amine
Inchi Key	AAXLOBRJGXXFQF-GOSISDBHSA-N
Inchi ID	InChI=1S/C22H26N4S2/c1-15(2)13-18-14-27-22(25-18)24-17-9-7-16(8-10-17)11-12-23-21-26-19-5-3-4-6-20(19)28-21/h3-10,15,18H,11-14H2,1-2H3,(H,23,26)(H,24,25)/t18-/m1/s1
PubChem CID	46879692
ChEMBL	CHEMBL1076276
IUPHAR	N/A
BindingDB	50312029
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
Ki	712.0 nM	PMID19864135	BindingDB,ChEMBL

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