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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Galanin receptor type 2
Species	Rattus norvegicus (Rat)
Gene	Galr2
Synonym	GAL2 receptor GAL2-R GALNR2 GALR-2
Disease	N/A for non-human GPCRs
Length	372
Amino acid sequence	MNGSGSQGAENTSQEGGSGGWQPEAVLVPLFFALIFLVGTVGNALVLAVLLRGGQAVSTTNLFILNLGVADLCFILCCVPFQATIYTLDDWVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLALLFSGPYLSYYRQSQLANLTVCHPAWSAPRRRAMDLCTFVFSYLLPVLVLSLTYARTLRYLWRTVDPVTAGSGSQRAKRKVTRMIIIVAVLFCLCWMPHHALILCVWFGRFPLTRATYALRILSHLVSYANSCVNPIVYALVSKHFRKGFRKICAGLLRPAPRRASGRVSILAPGNHSGSMLEQESTDLTQVSEAAGPLVPPPALPNCTASSRTLDPAC
UniProt	O08726
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL5577
IUPHAR	244
DrugBank	N/A

Ligand

Name	CHEMBL473840
Molecular formula	C26H40N4O5
IUPAC name	(3S,6S,9S,12S)-3-benzyl-12-[(2S)-butan-2-yl]-6-[(2S,3R)-3-hydroxybutan-2-yl]-9-propan-2-yl-1,4,7,10-tetrazacyclododecane-2,5,8,11-tetrone
Molecular weight	488.629
Hydrogen bond acceptor	5
Hydrogen bond donor	5
XlogP	3.0
Synonyms	BDBM50256666 (3S,6S,9S,12S)-3-benzyl-12-sec-butyl-6-((2S,3R)-3-hydroxybutan-2-yl)-9-isopropyl-1,4,7,10-tetraazacyclododecane-2,5,8,11-tetraone
Inchi Key	DIDDMMTUXXHTQR-FELOTHHLSA-N
Inchi ID	InChI=1S/C26H40N4O5/c1-7-15(4)21-25(34)28-20(14(2)3)24(33)30-22(16(5)17(6)31)26(35)27-19(23(32)29-21)13-18-11-9-8-10-12-18/h8-12,14-17,19-22,31H,7,13H2,1-6H3,(H,27,35)(H,28,34)(H,29,32)(H,30,33)/t15-,16+,17+,19-,20-,21-,22-/m0/s1
PubChem CID	44571997
ChEMBL	CHEMBL473840
IUPHAR	N/A
BindingDB	50256666
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	574.0 nM	PMID19013063	BindingDB,ChEMBL

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