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GPCR

NameD(2) dopamine receptor
SpeciesRattus norvegicus (Rat)
GeneDrd2
SynonymD2 receptor
D2(415) and D2(444)
D2A and D2B
D2R
Dopamine D2 receptor
[ Show all ]
DiseaseN/A for non-human GPCRs
Length444
Amino acid sequenceMDPLNLSWYDDDLERQNWSRPFNGSEGKADRPHYNYYAMLLTLLIFIIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMIAIVWVLSFTISCPLLFGLNNTDQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRKRRKRVNTKRSSRAFRANLKTPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRMDAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSNPDSPAKPEKNGHAKIVNPRIAKFFEIQTMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFMKILHC
UniProtP61169
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL339
IUPHAR215
DrugBankN/A

Ligand

NameCHEMBL3215641
Molecular formulaC19H24Cl2N2O2S
IUPAC name(6aR)-2-(2-aminoethylsulfanyl)-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-10,11-diol;dihydrochloride
Molecular weight415.373
Hydrogen bond acceptor5
Hydrogen bond donor5
XlogPNone
SynonymsN/A
Inchi KeyAIEPZCOPLOSUKA-QCUBGVIVSA-N
Inchi IDInChI=1S/C19H22N2O2S.2ClH/c1-21-6-4-12-8-13(24-7-5-20)10-14-17(12)15(21)9-11-2-3-16(22)19(23)18(11)14;;/h2-3,8,10,15,22-23H,4-7,9,20H2,1H3;2*1H/t15-;;/m1../s1
PubChem CID53327662
ChEMBLCHEMBL3215641
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessPartition coefficient log P of this ligand is not available.

Experimental Data

ParameterValueReferenceDatabase source
EC5016.0 nMPMID21550699ChEMBL
Efficacy112.0 %PMID21550699ChEMBL
Ki9.6 nMPMID21550699ChEMBL

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