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GPCR

NamePlatelet-activating factor receptor
SpeciesRattus norvegicus (Rat)
GenePtafr
SynonymAGEPC receptor
PAF receptor
PAF-R
PAFr
DiseaseN/A for non-human GPCRs
Length341
Amino acid sequenceMEQNGSFRVDSEFRYTLFPIVYSVIFVLGVVANGYVLWVFATLYPSKKLNEIKIFMVNLTVADLLFLMTLPLWIVYYSNEGDWIVHKFLCNLAGCLFFINTYCSVAFLGVITYNRYQAVAYPIKTAQATTRKRGITLSLVIWISIAATASYFLATDSTNVVPKKDGSGNITRCFEHYEPYSVPILVVHIFITSCFFLVFFLIFYCNMVIIHTLLTRPVRQQRKPEVKRRALWMVCTVLAVFVICFVPHHVVQLPWTLAELGYQTNFHQAINDAHQITLCLLSTNCVLDPVIYCFLTKKFRKHLSEKFYSMRSSRKCSRATSDTCTEVMMPANQTPVLPLKN
UniProtP46002
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL4127
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL134025
Molecular formulaC16H22N4O
IUPAC name2-[4-(2,2-dimethylpropanoyl)piperazin-1-yl]-2-pyridin-3-ylacetonitrile
Molecular weight286.379
Hydrogen bond acceptor4
Hydrogen bond donor0
XlogP1.3
SynonymsBDBM50003500
SCHEMBL9852903
2-[4-(2,2-Dimethylpropionyl)-1-piperazinyl]-2-(3-pyridinyl)acetonitrile
[4-(2,2-Dimethyl-propionyl)-piperazin-1-yl]-pyridin-3-yl-acetonitrile
Inchi KeyAIFRPOVILWOZEW-UHFFFAOYSA-N
Inchi IDInChI=1S/C16H22N4O/c1-16(2,3)15(21)20-9-7-19(8-10-20)14(11-17)13-5-4-6-18-12-13/h4-6,12,14H,7-10H2,1-3H3
PubChem CID10085405
ChEMBLCHEMBL134025
IUPHARN/A
BindingDB50003500
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
ID50<5.0 mg.kg-1PMID1433215ChEMBL

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