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Name | Metabotropic glutamate receptor 1 |
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Species | Rattus norvegicus (Rat) |
Gene | Grm1 |
Synonym | mGluR1 SCAR13 mGlu1 receptor metabotropic glutamate receptor 1 wobl [ Show all ] |
Disease | N/A for non-human GPCRs |
Length | 1199 |
Amino acid sequence | MVRLLLIFFPMIFLEMSILPRMPDRKVLLAGASSQRSVARMDGDVIIGALFSVHHQPPAEKVPERKCGEIREQYGIQRVEAMFHTLDKINADPVLLPNITLGSEIRDSCWHSSVALEQSIEFIRDSLISIRDEKDGLNRCLPDGQTLPPGRTKKPIAGVIGPGSSSVAIQVQNLLQLFDIPQIAYSATSIDLSDKTLYKYFLRVVPSDTLQARAMLDIVKRYNWTYVSAVHTEGNYGESGMDAFKELAAQEGLCIAHSDKIYSNAGEKSFDRLLRKLRERLPKARVVVCFCEGMTVRGLLSAMRRLGVVGEFSLIGSDGWADRDEVIEGYEVEANGGITIKLQSPEVRSFDDYFLKLRLDTNTRNPWFPEFWQHRFQCRLPGHLLENPNFKKVCTGNESLEENYVQDSKMGFVINAIYAMAHGLQNMHHALCPGHVGLCDAMKPIDGRKLLDFLIKSSFVGVSGEEVWFDEKGDAPGRYDIMNLQYTEANRYDYVHVGTWHEGVLNIDDYKIQMNKSGMVRSVCSEPCLKGQIKVIRKGEVSCCWICTACKENEFVQDEFTCRACDLGWWPNAELTGCEPIPVRYLEWSDIESIIAIAFSCLGILVTLFVTLIFVLYRDTPVVKSSSRELCYIILAGIFLGYVCPFTLIAKPTTTSCYLQRLLVGLSSAMCYSALVTKTNRIARILAGSKKKICTRKPRFMSAWAQVIIASILISVQLTLVVTLIIMEPPMPILSYPSIKEVYLICNTSNLGVVAPVGYNGLLIMSCTYYAFKTRNVPANFNEAKYIAFTMYTTCIIWLAFVPIYFGSNYKIITTCFAVSLSVTVALGCMFTPKMYIIIAKPERNVRSAFTTSDVVRMHVGDGKLPCRSNTFLNIFRRKKPGAGNANSNGKSVSWSEPGGRQAPKGQHVWQRLSVHVKTNETACNQTAVIKPLTKSYQGSGKSLTFSDASTKTLYNVEEEDNTPSAHFSPPSSPSMVVHRRGPPVATTPPLPPHLTAEETPLFLADSVIPKGLPPPLPQQQPQQPPPQQPPQQPKSLMDQLQGVVTNFGSGIPDFHAVLAGPGTPGNSLRSLYPPPPPPQHLQMLPLHLSTFQEESISPPGEDIDDDSERFKLLQEFVYEREGNTEEDELEEEEDLPTASKLTPEDSPALTPPSPFRDSVASGSSVPSSPVSESVLCTPPNVTYASVILRDYKQSSSTL |
UniProt | P23385 |
Protein Data Bank | 1iss, 1isr, 1ewk |
GPCR-HGmod model | N/A |
3D structure model | This structure is from PDB ID 1iss. |
BioLiP | BL0023849, BL0023850,BL0023851, BL0011887,BL0011889, BL0011888,BL0011890 |
Therapeutic Target Database | N/A |
ChEMBL | CHEMBL4477 |
IUPHAR | 289 |
DrugBank | N/A |
Name | CHEMBL234138 |
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Molecular formula | C11H14NO5P |
IUPAC name | 2-amino-2-[(1S,2R,3R)-2-phenyl-3-phosphonocyclopropyl]acetic acid |
Molecular weight | 271.209 |
Hydrogen bond acceptor | 6 |
Hydrogen bond donor | 4 |
XlogP | -3.3 |
Synonyms | BDBM50207810 (2S,1''S,2''R,3''R)-2-(2''-phosphono-3''-phenylcyclopropyl)glycine |
Inchi Key | DLDXPEVIBANPLO-IVMBQPJMSA-N |
Inchi ID | InChI=1S/C11H14NO5P/c12-9(11(13)14)8-7(10(8)18(15,16)17)6-4-2-1-3-5-6/h1-5,7-10H,12H2,(H,13,14)(H2,15,16,17)/t7-,8-,9?,10+/m0/s1 |
PubChem CID | 44429225 |
ChEMBL | CHEMBL234138 |
IUPHAR | N/A |
BindingDB | 50207810 |
DrugBank | N/A |
Structure | ![]() |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
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EC50 | <1000000.0 nM | PMID17350267 | BindingDB,ChEMBL |
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