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GLASS

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GPCR

Name	Metabotropic glutamate receptor 2
Species	Rattus norvegicus (Rat)
Gene	Grm2
Synonym	glutamate receptor GPRC1B metabotropic glutamate receptor 2 mGlu2 receptor mGluR2
Disease	N/A for non-human GPCRs
Length	872
Amino acid sequence	MESLLGFLALLLLWGAVAEGPAKKVLTLEGDLVLGGLFPVHQKGGPAEECGPVNEHRGIQRLEAMLFALDRINRDPHLLPGVRLGAHILDSCSKDTHALEQALDFVRASLSRGADGSRHICPDGSYATHSDAPTAVTGVIGGSYSDVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDYFARTVPPDFFQAKAMAEILRFFNWTYVSTVASEGDYGETGIEAFELEARARNICVATSEKVGRAMSRAAFEGVVRALLQKPSARVAVLFTRSEDARELLAATQRLNASFTWVASDGWGALESVVAGSERAAEGAITIELASYPISDFASYFQSLDPWNNSRNPWFREFWEERFHCSFRQRDCAAHSLRAVPFEQESKIMFVVNAVYAMAHALHNMHRALCPNTTHLCDAMRPVNGRRLYKDFVLNVKFDAPFRPADTDDEVRFDRFGDGIGRYNIFTYLRAGSGRYRYQKVGYWAEGLTLDTSFIPWASPSAGPLPASRCSEPCLQNEVKSVQPGEVCCWLCIPCQPYEYRLDEFTCADCGLGYWPNASLTGCFELPQEYIRWGDAWAVGPVTIACLGALATLFVLGVFVRHNATPVVKASGRELCYILLGGVFLCYCMTFVFIAKPSTAVCTLRRLGLGTAFSVCYSALLTKTNRIARIFGGAREGAQRPRFISPASQVAICLALISGQLLIVAAWLVVEAPGTGKETAPERREVVTLRCNHRDASMLGSLAYNVLLIALCTLYAFKTRKCPENFNEAKFIGFTMYTTCIIWLAFLPIFYVTSSDYRVQTTTMCVSVSLSGSVVLGCLFAPKLHIILFQPQKNVVSHRAPTSRFGSAAPRASANLGQGSGSQFVPTVCNGREVVDSTTSSL
UniProt	P31421
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL2851
IUPHAR	290
DrugBank	N/A

Ligand

Name	CHEMBL400018
Molecular formula	C24H18N2O2
IUPAC name	4-(3-methoxyphenyl)-8-(2-phenylethynyl)-1,3-dihydro-1,5-benzodiazepin-2-one
Molecular weight	366.42
Hydrogen bond acceptor	3
Hydrogen bond donor	1
XlogP	4.4
Synonyms	4-(3-Methoxy-phenyl)-8-phenylethynyl-1,3-dihydro-benzo[b][1,4]diazepin-2-one (E)-4-(3-methoxyphenyl)-8-(2-phenylethynyl)-1H-benzo[b][1,4]diazepin-2(3H)-one SCHEMBL5869015 4-(3-Methoxy-phenyl)-8-phenylethynyl-1,3-dihydro-benzo [b][1,4]diazepin-2-one BDBM50225813 DLLZKQWDMQYPFQ-UHFFFAOYSA-N [ Show all ]
Inchi Key	DLLZKQWDMQYPFQ-UHFFFAOYSA-N
Inchi ID	InChI=1S/C24H18N2O2/c1-28-20-9-5-8-19(15-20)22-16-24(27)26-23-14-18(12-13-21(23)25-22)11-10-17-6-3-2-4-7-17/h2-9,12-15H,16H2,1H3,(H,26,27)
PubChem CID	22224730
ChEMBL	CHEMBL400018
IUPHAR	N/A
BindingDB	50225813
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	962.0 nM	PMID17964783	ChEMBL

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