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GPCR

Name5-hydroxytryptamine receptor 1A
SpeciesRattus norvegicus (Rat)
GeneHtr1a
Synonym5-HT1A receptor
5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled
5-HT1A
ADRB2RL1
ADRBRL1
[ Show all ]
DiseaseN/A for non-human GPCRs
Length422
Amino acid sequenceMDVFSFGQGNNTTASQEPFGTGGNVTSISDVTFSYQVITSLLLGTLIFCAVLGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCCTSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGWRTPEDRSDPDACTISKDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVRKVEKKGAGTSLGTSSAPPPKKSLNGQPGSGDWRRCAENRAVGTPCTNGAVRQGDDEATLEVIEVHRVGNSKEHLPLPSESGSNSYAPACLERKNERNAEAKRKMALARERKTVKTLGIIMGTFILCWLPFFIVALVLPFCESSCHMPALLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKFCRR
UniProtP19327
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL273
IUPHAR1
DrugBankN/A

Ligand

NameCHEMBL150109
Molecular formulaC24H25Cl2N3O
IUPAC name(3,4-dichlorophenyl)-[4-[[(3-pyrrol-1-ylphenyl)methylamino]methyl]piperidin-1-yl]methanone
Molecular weight442.384
Hydrogen bond acceptor2
Hydrogen bond donor1
XlogP4.8
SynonymsN/A
Inchi KeyAIMARXRAQSIWCL-UHFFFAOYSA-N
Inchi IDInChI=1S/C24H25Cl2N3O/c25-22-7-6-20(15-23(22)26)24(30)29-12-8-18(9-13-29)16-27-17-19-4-3-5-21(14-19)28-10-1-2-11-28/h1-7,10-11,14-15,18,27H,8-9,12-13,16-17H2
PubChem CID10575180
ChEMBLCHEMBL150109
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Ki295.12 nMPMID9836623ChEMBL

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