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GPCR

NameCorticotropin-releasing factor receptor 1
SpeciesRattus norvegicus (Rat)
GeneCrhr1
SynonymCRH-R1
CRH-R-1
CRFR1
CRFR-1
CRF1 receptor
[ Show all ]
DiseaseN/A for non-human GPCRs
Length415
Amino acid sequenceMGRRPQLRLVKALLLLGLNPVSTSLQDQRCENLSLTSNVSGLQCNASVDLIGTCWPRSPAGQLVVRPCPAFFYGVRYNTTNNGYRECLANGSWAARVNYSECQEILNEEKKSKVHYHVAVIINYLGHCISLVALLVAFVLFLRLRSIRCLRNIIHWNLISAFILRNATWFVVQLTVSPEVHQSNVAWCRLVTAAYNYFHVTNFFWMFGEGCYLHTAIVLTYSTDRLRKWMFVCIGWGVPFPIIVAWAIGKLHYDNEKCWFGKRPGVYTDYIYQGPMILVLLINFIFLFNIVRILMTKLRASTTSETIQYRKAVKATLVLLPLLGITYMLFFVNPGEDEVSRVVFIYFNSFLESFQGFFVSVFYCFLNSEVRSAIRKRWRRWQDKHSIRARVARAMSIPTSPTRVSFHSIKQSTAV
UniProtP35353
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL4649
IUPHAR212
DrugBankN/A

Ligand

NameCHEMBL2058604
Molecular formulaC19H18Cl2N4O
IUPAC name8-[(1S)-1-cyclopropylpropyl]-4-(2,4-dichlorophenyl)-6-methylpteridin-7-one
Molecular weight389.28
Hydrogen bond acceptor4
Hydrogen bond donor0
XlogP4.1
SynonymsBDBM50387609
Inchi KeyDMGVJAFDJFZIGT-HNNXBMFYSA-N
Inchi IDInChI=1S/C19H18Cl2N4O/c1-3-15(11-4-5-11)25-18-17(24-10(2)19(25)26)16(22-9-23-18)13-7-6-12(20)8-14(13)21/h6-9,11,15H,3-5H2,1-2H3/t15-/m0/s1
PubChem CID62705994
ChEMBLCHEMBL2058604
IUPHARN/A
BindingDB50387609
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
IC5024.0 nMPMID22749422BindingDB,ChEMBL

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