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GPCR

Name	fMet-Leu-Phe receptor
Species	Homo sapiens (Human)
Gene	FPR1
Synonym	NFPR N-formylpeptide chemoattractant receptor N-formyl peptide receptor FPR1 FPR formyl peptide receptor 1 fMLP receptor fMLF-R [ Show all ]
Disease	Inflammatory disease Peptic ulcer
Length	350
Amino acid sequence	METNSSLPTNISGGTPAVSAGYLFLDIITYLVFAVTFVLGVLGNGLVIWVAGFRMTHTVTTISYLNLAVADFCFTSTLPFFMVRKAMGGHWPFGWFLCKFVFTIVDINLFGSVFLIALIALDRCVCVLHPVWTQNHRTVSLAKKVIIGPWVMALLLTLPVIIRVTTVPGKTGTVACTFNFSPWTNDPKERINVAVAMLTVRGIIRFIIGFSAPMSIVAVSYGLIATKIHKQGLIKSSRPLRVLSFVAAAFFLCWSPYQVVALIATVRIRELLQGMYKEIGIAVDVTSALAFFNSCLNPMLYVFMGQDFRERLIHALPASLERALTEDSTQTSDTATNSTLPSAEVELQAK
UniProt	P21462
Protein Data Bank	N/A
GPCR-HGmod model	P21462
3D structure model	This predicted structure model is from GPCR-EXP P21462.
BioLiP	N/A
Therapeutic Target Database	T87831
ChEMBL	CHEMBL3359
IUPHAR	222
DrugBank	BE0000995

Ligand

Name	cid_660196
Molecular formula	C19H12ClN3O4
IUPAC name	5-(3-chlorophenyl)-4-(furan-2-carbonyl)-1-pyrimidin-2-ylpyrrolidine-2,3-dione
Molecular weight	381.772
Hydrogen bond acceptor	6
Hydrogen bond donor	0
XlogP	2.7
Synonyms	2-(3-chlorophenyl)-3-(furan-2-ylcarbonyl)-4-oxidanyl-1-pyrimidin-2-yl-2H-pyrrol-5-one 5-(3-chlorophenyl)-4-(2-furoyl)-3-hydroxy-1-(2-pyrimidyl)-3-pyrrolin-2-one 2-(3-chlorophenyl)-3-[2-furanyl(oxo)methyl]-4-hydroxy-1-(2-pyrimidinyl)-2H-pyrrol-5-one BDBM34173
Inchi Key	DMPPKPOTCKPWDT-UHFFFAOYSA-N
Inchi ID	InChI=1S/C19H12ClN3O4/c20-12-5-1-4-11(10-12)15-14(16(24)13-6-2-9-27-13)17(25)18(26)23(15)19-21-7-3-8-22-19/h1-10,14-15H
PubChem CID	91896199
ChEMBL	N/A
IUPHAR	N/A
BindingDB	34173
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	<66700.0 nM	N/A	BindingDB
Ki	<43700.0 nM	N/A	BindingDB

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