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GPCR

NamefMet-Leu-Phe receptor
SpeciesHomo sapiens (Human)
GeneFPR1
SynonymNFPR
N-formylpeptide chemoattractant receptor
N-formyl peptide receptor
FPR1
FPR
[ Show all ]
DiseaseInflammatory disease
Peptic ulcer
Length350
Amino acid sequenceMETNSSLPTNISGGTPAVSAGYLFLDIITYLVFAVTFVLGVLGNGLVIWVAGFRMTHTVTTISYLNLAVADFCFTSTLPFFMVRKAMGGHWPFGWFLCKFVFTIVDINLFGSVFLIALIALDRCVCVLHPVWTQNHRTVSLAKKVIIGPWVMALLLTLPVIIRVTTVPGKTGTVACTFNFSPWTNDPKERINVAVAMLTVRGIIRFIIGFSAPMSIVAVSYGLIATKIHKQGLIKSSRPLRVLSFVAAAFFLCWSPYQVVALIATVRIRELLQGMYKEIGIAVDVTSALAFFNSCLNPMLYVFMGQDFRERLIHALPASLERALTEDSTQTSDTATNSTLPSAEVELQAK
UniProtP21462
Protein Data BankN/A
GPCR-HGmod modelP21462
3D structure modelThis predicted structure model is from GPCR-EXP P21462.
BioLiPN/A
Therapeutic Target DatabaseT87831
ChEMBLCHEMBL3359
IUPHAR222
DrugBankBE0000995

Ligand

Namecid_660196
Molecular formulaC19H12ClN3O4
IUPAC name5-(3-chlorophenyl)-4-(furan-2-carbonyl)-1-pyrimidin-2-ylpyrrolidine-2,3-dione
Molecular weight381.772
Hydrogen bond acceptor6
Hydrogen bond donor0
XlogP2.7
Synonyms2-(3-chlorophenyl)-3-(furan-2-ylcarbonyl)-4-oxidanyl-1-pyrimidin-2-yl-2H-pyrrol-5-one
5-(3-chlorophenyl)-4-(2-furoyl)-3-hydroxy-1-(2-pyrimidyl)-3-pyrrolin-2-one
2-(3-chlorophenyl)-3-[2-furanyl(oxo)methyl]-4-hydroxy-1-(2-pyrimidinyl)-2H-pyrrol-5-one
BDBM34173
Inchi KeyDMPPKPOTCKPWDT-UHFFFAOYSA-N
Inchi IDInChI=1S/C19H12ClN3O4/c20-12-5-1-4-11(10-12)15-14(16(24)13-6-2-9-27-13)17(25)18(26)23(15)19-21-7-3-8-22-19/h1-10,14-15H
PubChem CID91896199
ChEMBLN/A
IUPHARN/A
BindingDB34173
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
IC50<66700.0 nMN/ABindingDB
Ki<43700.0 nMN/ABindingDB

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